CYP2E1 Antikörper (C-Term)

Produktnummer ABIN310147

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CYP2E1 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Kaninchen, Hund, Pferd, Meerschweinchen, Rind (Kuh) und Schaf.

Kurzübersicht für CYP2E1 Antikörper (C-Term) (ABIN310147)

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Pferd, Meerschweinchen, Rind (Kuh), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2E1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CYP2E1 Antikörper

Bindungsspezifität: C-Term

Sequenz: QEFPDPEKFK PEHFLNENGK FKYSDYFKPF STGKRVCAGE GLARMELFLL

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 92%, Horse: 79%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 92%, Sheep: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CYP2E1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CYP2E1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 493 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CYP2E1

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Andere Bezeichnung: CYP2E1

Hintergrund: CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
Alias Symbols: CPE1, CYP2E, P450-J, P450C2E
Protein Interaction Partner: UBC, ABCA5, LAMC3, NMI, PTN, POR, MAFG, GATM, ECHS1, CYB5A, AGXT2, RPL13A, CLU, STUB1, AMFR, FANCG,
Protein Size: 493

Molekulargewicht: 54 kDa

Gen-ID: 1571

NCBI Accession: NM_000773, NP_000764

UniProt: P05181