CACNA1A Antikörper

Produktnummer ABIN306878

Der Kaninchen Polyklonal anti-CACNA1A Antikörper wird verwendet zum Nachweis von CACNA1A in Proben von Ratte. Er wurde validiert für WB.

Kurzübersicht für CACNA1A Antikörper (ABIN306878)

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNA1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CACNA1A Antikörper

Verwendungszweck: Rabbit anti Rat Calcium Channel

Produktmerkmale: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the rat 1A calcium channel conjugated to KLH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml

Buffer: phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu CACNA1A

Target: CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A))

Andere Bezeichnung: a1ACalcium Channel

Hintergrund: Voltage-gated calcium channel subunit alpha Cav2.1,Calcium channel, L type, alpha-1 polypeptide, isoform 4, Brain calcium channel I

UniProt: P54282

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process