Retinoblastoma-Like 1 (p107) (RBL1) Antikörper

Antigen: Retinoblastoma-Like 1 (p107) (RBL1)

Synonyme: PRB1, p107, CP107, MGC40006, AW547426, prb1, MGC84607, RBL1, fj58e06, wu:fj58e06

Klonalität: Monoklonal (KAB6)

Wirt: Maus

Reaktivität: Human, Maus, Ratte (Rattus)

Produktnummer: ABIN306628

Produktbeschreibung

Weitere Bezeichnung: p107

Swiss-Prot: P28749

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: KAB6

Beschreibung: The immunogen used was a GST fusion protein to the N terminus of p107. p107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors. KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107kDa. Synonyms: p107, Retinoblastoma-like protein 1, PRB1, 107 kda retinoblastoma-associated protein.

Anwendungen

Forschungsgebiet: Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar