BCL2A1 Antikörper

Produktnummer ABIN302791

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BCL2A1 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für BCL2A1 Antikörper (ABIN302791)

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BCL2A1 Antikörper

Spezifität: This antibody reacts to 14 amino acid peptide from near the amino terminus of Bfl-1.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 - 2 μg/mL. Immunohistochemistry: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Hintergrund: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

Gen-ID: 597

NCBI Accession: NP_004040

UniProt: Q16548