SIX3 Antikörper

Produktnummer ABIN272150

Der Kaninchen Polyklonal anti-SIX3 Antikörper wird verwendet zum Nachweis von SIX3 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IF.

Kurzübersicht für SIX3 Antikörper (ABIN272150)

Target: SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-SIX3 Antikörper

Spezifität: This antibody detects endogenous levels of Six3/6 protein. (region surrounding Asp228)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SIX3

Target: SIX3 (Sine Oculis-Related Homeobox 3 (SIX3))

Andere Bezeichnung: SIX3

Hintergrund: The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Two of these family members Six3 and Six6 (also designated Optx2 and Six9) are required for the specification and proliferation of the eye field in vertebrates, and, therefore, are the vertebrate homologues most closely related to the Drosophila sine oculis protein, which has an essential role in controlling compound eye development. Six3 and Six6 expression largely overlap during development of specific tissues, such as retina, hypothalamus, and pituitary. The human Six6 gene maps to chromosome 14q22.3-q23. Haploinsufficiency of Six6 may cause several developmental disorders, including bilateral anophthalmia and pituitary anomalies. The gene encoding the human Six3 protein maps to chromosome 2p21-p22, a region associated with holoprosencephaly type 2 (HPE2). Deletion of Six3 may be associated with HPE2 disorder, a common, severe malformation of the brain that results from incomplete cleavage of the forebrain during early embryogenesis.Synonyms: Homeobox protein SIX3, Sine oculis homeobox homolog 3

Molekulargewicht: approx. 28 kDa

Gen-ID: 6496

NCBI Accession: NP_005404

UniProt: O95343

Pathways: Protein targeting to Nucleus