Amyloid beta 1-42 (Abeta 1-42) Antikörper

Antigen: Amyloid beta 1-42 (Abeta 1-42)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB), ELISA, Dot Blot (Dot)

Produktnummer: ABIN249343

Produktbeschreibung

Weitere Bezeichnung: Amyloid-beta 42 protein (Abeta (1-42))

Immunogen: synthetic peptide chosen from human Abeta (1-42) protein. Amino acid sequence:D-A-E-F-R-H-D-S-G-Y-E-V-H-H-Q-K-L-V-F-F-A-E-D-V-G-S-N-K-G-A-I-I-G-L-M-V-G-G-V-V-I-A

Format: Lyophilized

Beschreibung: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growingpopulation of elderly people. A hallmark of AD is the accumulation of plaques in the brain ofAD patients. The plaques predominantly consist of aggregates of amyloid-beta (Abeta), apeptide of 39-42 amino acids generated in vivo by specific, proteolytic cleavage of the amyloidprecursor protein P05067

Spezifität: Predicted reactivity: bovine, chicken, dog, porcine, rabbit.

Anwendungen

Applikationshinweise: Recommended Dilution 1:3000 (ELISA), 1:1000 (DB).

Reinheit: Purified

Lagerung: store lyophilized/reconstituted at -20°C, once reconstituted make aliquots to avoid repeatedfreeze-thaw cycles. Please, remember to spin tubes briefly prior to opening them to avoid anylosses that might occur from lyophilized material adhering to the cap or sides of the tubes.

Forschungsgebiet: Neurologie, Alzheimer-Krankheit (Morbus Alzheimer)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

beta(1-42) consists of both monomeric and partly aggregated mtrl

Publikationen

Publikationen: Lindhagen-Persson, Bra?nnstra?m, Vestling et al.: "Amyloid-β oligomer specificity mediated by the IgM isotype--implications for a specific protective mechanism exerted by endogenous auto-antibodies." in: PLoS ONE, Vol. 5, Issue 11, pp. e13928, 2010 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (1:1000).