HLA Class I ABC Antikörper (FITC)

Antigen: HLA Class I ABC

Klonalität: Monoklonal (W6-32)

Wirt: Maus

Reaktivität: Rind (Kuh)

Konjugat: FITC

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN238526

Produktbeschreibung

Produktmerkmale: Synonyms: HLA-ABC, HLA class I histocompatibility antigen, MHC class I antigen

Immunogen: Membrane of human tonsil cells. Remarks: Gene Locus: 6p21. 3

Kreuzreaktivität: Rind (Kuh), Katze, Human

Isotyp: IgG2a

Klon: W6-32

Beschreibung: HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteinsexpressed on nucleated cells and noncovalently associated with an invariant beta-2microglobulin. They carry foreign determinants important for immune recognition bycytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class Iantigens are represented by HLA-A, HLA-B and HLA-C molecules. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.

Spezifität: The antibody W6/32 recognizes virtually all nucleated human cells. It is a valuable reagentfor analysing variations in HLA class I expression in different disease states e. g. liverdisease, muscular dystrophy, inflammatory myopathy and other neuromuscular disorders. This antibody W6/32 is also suitable as a positive control for HLA tissue typing andcrossmatching. Species: Human, Non-Human Primates, Bovine, Feline (Cat). Does not work in Rabbit. Others not tested.

Anwendungen

Applikationshinweise: Flow Cytometry (starting dilution 1/300). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Konzentration: 1.0 mg/ml

Buffer: Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative,approx. pH 7.4Label: Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free ofunconjugated FITC.

Lagerung: Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Shelf life: one year from despatch.

Forschungsgebiet: Haupthistokompatibilitätskomplex (MHC)

Beschränkungen: Nur für Forschungszwecke einsetzbar