»
Antikörper
»
anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) Antikörper (APC)
Platelet/endothelial Cell Adhesion Molecule (PECAM1) Antikörper (APC)
| Antigen |
|
| Synonyme |
CD31, PECAM-1, FLJ58394, Cd31, Pecam, C85791, MGC102160, MGC124998, PECAM1 |
| Klonalität |
Monoklonal (MEM-05) |
|
Wirt
|
|
|
Reaktivität
|
Human (208), Maus (136), Ratte (Rattus) (61), Hund (35), Schwein (35), Pferd (18), Kaninchen (18), Affe (9), Rind (Kuh) (8), Schaf (7), Huhn (2), Ziege (1)
|
|
Konjugat
|
FITC (38), PE (27), Biotin (26), APC (13), Alexa Fluor 488 (9), Alexa Fluor 647 (8), PE,Cy7 (8), RPE (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), EFluor 605NC (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), RBITC (2), Alexa Fluor 700 (1), PE,DY590 (1), PE-Dyomics 590 (1), Pacific Blue (1), PerCP (1)
|
|
Applikation
|
Durchflusszytometrie (FACS) (259), Western Blot (WB) (82), Immunfluoreszenz (IF) (70), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (62), Immunhistochemie (Paraffinschnitte) (IHC (p)) (58), Immunpräzipitation (IP) (50), Immunhistochemie (IHC) (32), ELISA (17), Enzyme Immunoassay (EIA) (17), Funktionale Studien (Func) (7), Blockierende Antikörper (Inhibition) (5), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (5), ELISA (Detektionsantikörper) (3), Dot Blot (Dot) (2), Immunoassay (IA) (1), Immunelektronenmikroskopie (EM) (1), Immunoelectron Microscopy (IEM) (1)
|
| Produktnummer |
ABIN238441 |
| Menge |
100 Tests |
| Preis |
260,00 € Zzgl. Versandkosten €20,00 und MWSt
|
| Lieferung nach |
|
| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
|
Produktmerkmale
|
Synonyms: PECAM-1, EndoCAM, GPIIA', Platelet endothelial cell adhesion molecule
|
|
Weitere Bezeichnung
|
CD31 / PECAM1
|
|
Swiss-Prot
|
P16284
|
|
Immunogen
|
Leukocytes of patient suffering from LGL-type leukaemia
|
|
Kreuzreaktivität
|
Human
|
|
Isotyp
|
IgG1
|
|
Klon
|
MEM-05
|
|
Beschreibung
|
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptorinvolved in rebulation of T cell and B cell signaling by a dual immunoreceptortyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediatedphosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly atjunctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for itshomophilic binding, which plays an important role in cell-cell interactions. CD31 is amultifunctional molecule with diverse roles in modulation of integrin-mediated celladhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation ofimmunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediatedanaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
|
|
Spezifität
|
The antibody MEM-05 reacts with CD31 (PECAM-1), a 130-140 kDa type I transmembraneglycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells and stemcells of the myeloid lineage. Species: Human. Others not tested.
|
|
Buffer
|
PBS containing 15 mM sodium azide as preservative and 0.2% (w/v)high-grade BSA (Protease free) as stabilizer.Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions.
|
|
Lagerung
|
Store the antibody in the dark at 2-8°C. Do Not Freeze! Avoid prolonged exposure to light. Shelf life: One year from despatch.
|
|
Forschungsgebiet
|
CD Antigene, Oberflächenrezeptoren der Immunzellen
|
|
Beschränkungen
|
Nur für Forschungszwecke einsetzbar
|
Alternativen zu Antigen "Platelet/endothelial Cell Adhesion Molecule (PECAM1)", Typ "Antikörper" finden
|
Wirte
|
Maus (179), Ratte (80), Kaninchen (70), Hamster (3), Schaf (1)
|
|
Reaktivitäten
|
Human (208), Maus (136), Ratte (Rattus) (61), Hund (35), Schwein (35), Pferd (18), Kaninchen (18), Affe (9), Rind (Kuh) (8), Schaf (7), Huhn (2), Ziege (1)
|
|
Applikationen
|
Durchflusszytometrie (FACS) (259), Western Blot (WB) (82), Immunfluoreszenz (IF) (70), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (62), Immunhistochemie (Paraffinschnitte) (IHC (p)) (58), Immunpräzipitation (IP) (50), Immunhistochemie (IHC) (32), ELISA (17), Enzyme Immunoassay (EIA) (17), Funktionale Studien (Func) (7), Blockierende Antikörper (Inhibition) (5), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (5), ELISA (Detektionsantikörper) (3), Dot Blot (Dot) (2), Immunoassay (IA) (1), Immunelektronenmikroskopie (EM) (1), Immunoelectron Microscopy (IEM) (1)
|
|
Konjugate
|
FITC (38), PE (27), Biotin (26), APC (13), Alexa Fluor 488 (9), Alexa Fluor 647 (8), PE,Cy7 (8), RPE (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), EFluor 605NC (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), RBITC (2), Alexa Fluor 700 (1), PE,DY590 (1), PE-Dyomics 590 (1), Pacific Blue (1), PerCP (1)
|
|
Epitope
|
C-Term (13), pTyr713 (1)
|
Alternativen 
