Clusterin (CLU) Antikörper

Antigen: Clusterin (CLU)

Synonyme: Cli, ApoJ, Sgp2, SP-40, Sgp-2, Sugp-2, AI893575, D14Ucla3, CLU, LOC100136120, CLI, AAG4, APOJ, KUB1, SGP2, SGP-2, TRPM2, TRPM-2, MGC24903, DAG, SP40, Trpm2, Trpmb, TRPM2B, RATTRPM2B, gpIII, clu, MGC53055, MGC73352, zgc:73352, GP80, xclu, MGC89163, LOC100034172

Klonalität: Monoklonal (Hs-3)

Wirt: Maus

Reaktivität: Human

Applikation: Enzyme Immunoassay (EIA), Immunfluoreszenz (IF), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)

Produktnummer: ABIN238421

Produktbeschreibung

Produktmerkmale: Synonyms: Clusterin, APOJ, CLI, KUB1, AAG4, NA1/NA2, SP-40, 40, Complement-associated proteinSP-40, Complement cytolysis inhibitor, Testosterone-repressed prostate message 2,Ku70-binding protein 1, Aging-associated gene 4 protein

Weitere Bezeichnung: Apolipoprotein J (Apo J)

Swiss-Prot: P10909

Immunogen: Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid,10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0. 2% acetic acid and subsequently used forimmunization.

Kreuzreaktivität: Human

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: Hs-3

Beschreibung: Clusterin (APO J, SGP-2, TRPM-2, SP-40, pADHC-9, CLJ, T64, GP III, XIP8) is a 75-80 kDdisulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate richin sialic acid but truncated forms targeted to the nucleus have also been identified. It is aconserved secreted glycoprotein expressed by a wide range of tissues and beingimplicated in many physiological processes, including e. g. lipid transportation,complement inhibition, tissue remodeling, membrane recycling, or clearence of cellulardebris. It is nearly ubiqitously expressed in most mammalian tissues and can be found inplasma, milk, urine, cerebrospinal fluid and semen. Clusterin is able to bind and formcomplexes with numerous partners (immunoglobulins, lipids, heparin, bacteria,complement components, paraoxonase, beta amyloid, leptin etc. ) and is expressed inmany pathological and clinically relevant situations including cancer, organ regeneration,infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubulardamage, autoimmunity and others. A genuine function of clusterin is still enigmatic.

Spezifität: Recognizes Apolipoprotein J (Apo J). Species Reactivity: Tested: Human. Negative in Bovine, Canine (Dog) and Feline (Cat).

Synonyme: Cli, ApoJ, Sgp2, SP-40, Sgp-2, Sugp-2, AI893575, D14Ucla3, CLU, LOC100136120, CLI, AAG4, APOJ, KUB1, SGP2, SGP-2, TRPM2, TRPM-2, MGC24903, DAG, SP40, Trpm2, Trpmb, TRPM2B, RATTRPM2B, gpIII, clu, MGC53055, MGC73352, zgc:73352, GP80, xclu, MGC89163, LOC100034172

Anwendungen

Applikationshinweise: ELISA. Western blot: 1/ µg/mlPositive Material: seminal plasmaImmunocytochemistry. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Positive Tissue: Sertoli cells.

Konzentration: 1.0 mg/ml

Reinigung: Aff - Purified

Buffer: PBS, pH~7.4 with 15 mM Sodium Azide as preservative

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Forschungsgebiet: Metabolismus, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar