LEF1 Antikörper (AA 256-297)

Produktnummer ABIN187662

Der Maus Monoklonal anti-LEF1 Antikörper (Klon 2F4-1D10) (ABIN187662) detektiert spezifisch LEF1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für LEF1 Antikörper (AA 256-297) (ABIN187662)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LEF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 2F4-1D10

Produktdetails anti-LEF1 Antikörper

Bindungsspezifität: AA 256-297

Spezifität: This antibody detects all isoforms of LEF-1 by Western blot. Does not crossreact with TCF-1 or TCF-4. Species Reactivity: Human. Others not tested.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant full length LEF-1 protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody 100 µg at 1.0 mg/mL. Provided as 0.2 µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Andere Bezeichnung: LEF1

Hintergrund: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others.

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding