DEAF1 Antikörper (C-Term)

Produktnummer ABIN183800

Der Kaninchen Polyklonal anti-DEAF1 Antikörper wird verwendet zum Nachweis von DEAF1 in Proben von Human, Maus, Ratte, Meerschweinchen, Hund, Pferd und Schwein. Er wurde validiert für WB.

Kurzübersicht für DEAF1 Antikörper (C-Term) (ABIN183800)

Target: DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Hund, Pferd, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DEAF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DEAF1 Antikörper

Bindungsspezifität: C-Term

Sequenz: TGCHKVNYCS TFCQRKDWKD HQHICGQSAA VTVQADEVHV AESVMEKVTV

Homologie: Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Pig: 93%, Rat: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against DEAF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DEAF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 565 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DEAF1

Target: DEAF1 (Deformed Epidermal Autoregulatory Factor 1 (Drosophila) (DEAF1))

Andere Bezeichnung: DEAF1

Hintergrund: DEAF1 down-regulates transcription of those genes by binding to sequence with multiple copies of TTC[CG]G present in their own promoter and that of the HNRPA2B1 gene. DEAF1 binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. DEAF1 activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.
Alias Symbols: SPN, NUDR, ZMYND5
Protein Interaction Partner: IRF7, IRF3, CREB1, PELI1, PELI2, HRSP12, GSK3B, GSK3A, CDKN2A, PPP1CC, PPP1CA, CDC37, AIMP2, TK1, RAD23B, PIN1, HRAS, FHL1, CDKN1A, ASCC2, INTS1, LMO4, DEAF1,
Protein Size: 565

Molekulargewicht: 59 kDa

Gen-ID: 10522

NCBI Accession: NM_021008, NP_066288

UniProt: O75398

Pathways: Tube Formation