LAMP1 Antikörper

Produktnummer ABIN135831

Produktdetails anti-LAMP1 Antikörper

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAMP1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Spezifität: Human/Rhesus/African Green Monkey/Pigtail Macaque/Sooty Mangabey CD107a, Mr 100-120 kDa

Produktmerkmale: Mouse Anti-Human CD107a-UNLB

Aufreinigung: Purified

Immunogen: Human adherent peripheral blood cells

Klon: H4A3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working Dilution:
FACS: 1 µg/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Product is supplied as 0.1 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Referenzen für anti-LAMP1 Antikörper (ABIN135831)

Eriksson, Wäster, Öllinger: "Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins." in: Cell death & disease, Vol. 11, Issue 5, pp. 370, (2020) (PubMed).

Remacle, Hullugundi, Dolkas, Angert, Cieplak, Scott, Chernov, Shubayev, Strongin: "Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism." in: The Biochemical journal, Vol. 475, Issue 14, pp. 2355-2376, (2019) (PubMed).

Boman, Svensson, Boxer, Rojas, Seeley, Karydas, Miller, Kågedal, Svenningsson: "Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid." in: Journal of Parkinson's disease, Vol. 6, Issue 2, pp. 307-15, (2016) (PubMed).

Armstrong, Mattsson, Appelqvist, Janefjord, Sandin, Agholme, Olsson, Svensson, Blennow, Zetterberg, Kågedal: "Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease." in: Neuromolecular medicine, Vol. 16, Issue 1, pp. 150-60, (2014) (PubMed).

Details zu LAMP1

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Andere Bezeichnung: CD107a (LAMP1 Produkte)

Synonyme: CD107a antikoerper, LAMPA antikoerper, LGP120 antikoerper, AI196048 antikoerper, Lamp-1 antikoerper, LEP100 antikoerper, LAMP-1 antikoerper, LGP-A antikoerper, Lgpa antikoerper, Lysosome-associated membrane protein 1 antikoerper, cd107a antikoerper, lamp-1 antikoerper, lamp1 antikoerper, lampa antikoerper, lgp120 antikoerper, rexp76 antikoerper, lysosomal associated membrane protein 1 antikoerper, lysosomal-associated membrane protein 1 antikoerper, lysosomal-associated membrane protein 1 L homeolog antikoerper, LAMP1 antikoerper, Lamp1 antikoerper, lamp1.L antikoerper

Hintergrund: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Pathways: Autophagie