FAS Antikörper

Produktnummer ABIN135822

Der Maus Monoklonal anti-FAS Antikörper (Klon DX3) (ABIN135822) detektiert spezifisch FAS in FACS, ELISA und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für FAS Antikörper (ABIN135822)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAS Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: DX3

Produktdetails anti-FAS Antikörper

Verwendungszweck: Mouse Anti-Human CD95-LE/AF

Spezifität: Human/Rat CD95, Mr 45 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Human CD95 antibody for use in flow cytometry, ELISA, immunohistochemistry assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Human CD95 transfected L cells

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Andere Bezeichnung: CD95

Hintergrund: CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95.

Gen-ID: 355

UniProt: P25445

Pathways: p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity