BOK Antikörper

Produktnummer ABIN126989

Der Kaninchen Polyklonal anti-BOK Antikörper wird verwendet zum Nachweis von BOK in Proben von Ratte. Er wurde validiert für WB.

Kurzübersicht für BOK Antikörper (ABIN126989)

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BOK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-BOK Antikörper

Spezifität: This antibody reacts to Bok.

Aufreinigung: Affinity purified

Immunogen: Synthetic peptide surrounding amino acid 44 of rat BOK.

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu BOK

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Andere Bezeichnung: BOK / BCL2L9

Hintergrund: Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.Synonyms: Bcl-2-like protein 9, Bcl-2-related ovarian killer protein, Bcl2-L-9, Hbok

Gen-ID: 29884

NCBI Accession: NP_059008

UniProt: Q792S6

Pathways: Positive Regulation of Endopeptidase Activity