CD191 / CCR1 (Extracell. Dom.) Antikörper

Antigen: CD191 / CCR1 (Extracell. Dom.)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN121947

Produktbeschreibung

Swiss-Prot: P32246

Immunogen: Synthetic petide - KLH conjugated.

Beschreibung: CCR1, a Chemokine Receptor, affects stem cell proliferation and mediates systemic inflammatory responses. This receptor is stimulated by the beta chemokines RANTES, MCP-1, and MIP-1 alpha. Disruption of CCR1 enhances protection from pulmonary inflammation and reduces the development of respiratory distress syndrome in rat. CCR1 is widely expressed, particularly in hematopoietic cells from blood, vessels, and bone marrow. This receptor has also been reported to be expressed in lung, brain, placenta, heart, skeletal muscle, and kidney. ESTs have been isolated from blood, kidney, liver/spleen, lung, placenta, uterus, and vessel libraries. Alternate Names: CD191 antigen, MIP-1alpha-R, RANTES-R, CMKBR1, CMKR1, SCYAR1.

Spezifität: Reacts with human C-C Chemokine Receptor 1 (CCR1,.The immunizing peptide shows 85% identity (85% similarity) with mouse and 75% identity (80% similarity) with rat

Anwendungen

Applikationshinweise: Immunohistochemistry on paraffin embedded sections: 5 ug/ml. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100°C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Konzentration: 1 mg/ml

Buffer: PBS, pH 7.7, containing 0.01% sodium azide

Lagerung: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C forlonger. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemical staining of CCR1 on human spleen sections using antibody #ABIN121947.