LCP2 Antikörper (AA 216-434)

Produktnummer ABIN120741

Der Maus Monoklonal anti-LCP2 Antikörper (Klon SLP-76-03) (ABIN120741) detektiert spezifisch LCP2 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Schwein.

Kurzübersicht für LCP2 Antikörper (AA 216-434) (ABIN120741)

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Reaktivität: Human, Maus, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LCP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: SLP-76-03

Produktdetails anti-LCP2 Antikörper

Bindungsspezifität: AA 216-434

Spezifität: The antibody reacts with SLP76, a 76 kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils, in B cells, however, it is replaced by SLP65.

Aufreinigung: Protein G affinity chromatography

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: A fusion protein representing amino acids 216-434 of human SLP-76

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Haltbarkeit: 12 months

Details zu LCP2

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Andere Bezeichnung: LCP2

Hintergrund: SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets, B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-g. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.Synonyms: LCP2, Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76

Gen-ID: 3937

UniProt: Q13094

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung