ING4 Antikörper (Isoform 1)

Produktnummer ABIN118054

Dieser Ziege Polyklonal Antikörper detektiert spezifisch ING4 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Huhn und Affe. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für ING4 Antikörper (Isoform 1) (ABIN118054)

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Reaktivität: Human, Maus, Ratte, Hund, Huhn, Affe

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ING4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ING4 Antikörper

Bindungsspezifität: AA 164-175, Isoform 1

Sequenz: Protein sequence for Human p29 ING4 isoform 1, 249 aa, predicted MW 28.5 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrtedlka eidklateym ssarslssee 61 klallkqiqe aygkckefgd dkvqlamqty emvdkhirrl dtdlarfead lkekqiessd 121 ydsssskgkk kgrtqkekka ararskgkns deeapktaqk klklvrtspe ygmpsvtfgs 181 vhpsdvldmp vdpneptycl chqvsygemi gcdnpdcsie wfhfacvglt tkprgkwfcp 241 rcsqerkkk Protein sequence for Human p29 ING4 isoform 2, 47 aa, predicted MW 5.6 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrteeald tissleh

Spezifität: Reactivity occurs against human p29 ING4 protein. 100 % homology is on record for this protein from human, dog, rat, and mouse. Cross reactivity with p29 ING4 protein from chimpanzee and chicken sources is also expected based on high homology (one amino acid change in sequence) by BLAST. Reactivity with p29 ING4 proteins from other sources is not known.

Aufreinigung: Immunoaffinity chromatography.

Immunogen: A synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein. This sequence only shows homology to isoform 1 for ING4. Genename: ING4

Anwendungsinformationen

Applikationshinweise: Antibody R1606P has been tested for use in ELISA (1: 3,000-1: 12,000) against theimmunizing peptide. Specific conditions for Western blotting (1: 500-1: 3,000) reactivity

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.28 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C. DO NOT FREEZE!

Referenzen für anti-ING4 Antikörper (ABIN118054)

Wang, He, Wang, Wang, Zhai, Zhou, Zhang, Zhai, Feng, Han: "[Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.]" in: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 111-5, (2008) (PubMed).

Kim, Choi, Park, Han, Kim, Chu, Kim: "Endometrial stromal sarcoma of the small bowel: a case report and review of literature." in: Annals of diagnostic pathology, Vol. 12, Issue 2, pp. 128-33, (2008) (PubMed).

Details zu ING4

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Andere Bezeichnung: ING4

Hintergrund: P29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA. p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) that encodes the longest isoform.Synonyms: Inhibitor of growth protein 4, My036, p29ING4

Gen-ID: 51147

NCBI Accession: NP_001121054

UniProt: Q9UNL4