ING4 Antikörper (C-Term)

Produktnummer ABIN1944775

Produktdetails anti-ING4 Antikörper

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Bindungsspezifität: AA 162-195, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ING4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, C, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

Klon: RB47839

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ING4 Antikörper (ABIN1944775)

Raho, Miranda, Tamborini, Pierotti, Greco: "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene." in: Oncogene, Vol. 26, Issue 36, pp. 5247-57, (2007) (PubMed).

Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity." in: Cancer research, Vol. 63, Issue 10, pp. 2373-8, (2003) (PubMed).

Details zu ING4

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Andere Bezeichnung: ING4 (ING4 Produkte)

Synonyme: wu:fb11d09 antikoerper, wu:fb50e02 antikoerper, zgc:110619 antikoerper, ING4 antikoerper, my036 antikoerper, p29ING4 antikoerper, D6Wsu147e antikoerper, D6Xrf92 antikoerper, inhibitor of growth family, member 4 antikoerper, inhibitor of growth family member 4 antikoerper, ing4 antikoerper, ING4 antikoerper, Ing4 antikoerper

Hintergrund: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Molekulargewicht: 28530

Gen-ID: 51147

UniProt: Q9UNL4