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LEFTY2 Antikörper

LEFTY2 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Maus Monoclonal 7C5G1H6H10 unconjugated
Produktnummer ABIN116931
  • Target Alle LEFTY2 Antikörper anzeigen
    LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
    Reaktivität
    • 30
    • 13
    • 10
    • 3
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 33
    • 5
    • 2
    • 1
    Maus
    Klonalität
    • 36
    • 5
    Monoklonal
    Konjugat
    • 26
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LEFTY2 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 15
    • 14
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This protein A purified mouse monoclonal antibody reacts with a 30 kDa protein corresponding to human LEFTY. No reactivity occurs against 6X HIS tag. Significant sequence homology exists between the human and mouse forms of LEFTY. Cross reactivity is expected with mouse and rat forms of the protein. Reactivity with other sources has not been determined.
    Aufreinigung
    Protein A chromatography.
    Immunogen
    A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.
    Klon
    7C5G1H6H10
    Isotyp
    IgG2a
    Top Product
    Discover our top product LEFTY2 Primärantikörper
  • Applikationshinweise
    This antibody is suitable for ELISA (1/5,000) and Western blotting (1/2,000). The antibodymay be used for other applications, such as RIA, Immunohistochemistry orImmunoprecipitation, but specific reaction conditions have not been developed.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % sodium azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
    Andere Bezeichnung
    LEFTY2 (LEFTY2 Produkte)
    Synonyme
    EBAF antikoerper, LEFTA antikoerper, LEFTYA antikoerper, TGFB4 antikoerper, AI450052 antikoerper, Ebaf antikoerper, Leftb antikoerper, Stra3 antikoerper, Tgfb4 antikoerper, lefty antikoerper, lefty-1 antikoerper, atv2 antikoerper, cb720 antikoerper, fe38b03 antikoerper, wu:fe38b03 antikoerper, 6030463A22Rik antikoerper, AV214969 antikoerper, Lefta antikoerper, Ebaf2 antikoerper, left-right determination factor 2 antikoerper, left right determination factor 1 antikoerper, lefty2 antikoerper, Left-right determination factor 2 antikoerper, left-right determination factor 2-like antikoerper, LEFTY2 antikoerper, Lefty1 antikoerper, lft2 antikoerper, Lefty2 antikoerper, LOC699676 antikoerper, LOC100232580 antikoerper
    Hintergrund
    During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.Synonyms: EBAF, Endometrial bleeding-associated factor, LEFTA, LEFTY2, LEFTYA, Left-right determination factor 2, Left-right determination factor A, Protein lefty-2, Protein lefty-A, TGF-beta-4, TGFB4, Transforming growth factor beta-4
    Gen-ID
    7044
    NCBI Accession
    NP_003231
    UniProt
    O00292
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