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Desmocollin 1 Antikörper

DSC1 Reaktivität: Human WB, IHC (p), IHC (fro) Wirt: Maus Monoclonal Dsc-1-U100 unconjugated
Produktnummer ABIN112238
  • Target Alle Desmocollin 1 (DSC1) Antikörper anzeigen
    Desmocollin 1 (DSC1)
    Reaktivität
    • 37
    • 7
    • 3
    Human
    Wirt
    • 37
    • 2
    • 1
    Maus
    Klonalität
    • 37
    • 3
    Monoklonal
    Konjugat
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Desmocollin 1 Antikörper ist unkonjugiert
    Applikation
    • 30
    • 18
    • 13
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Sequenz
    HQTLESVKGV GQGDTGRYAT DWQC
    Spezifität
    Reacts with 111 kDa (form "a") and 103 kDa (form "b") polypeptides (Desmocollin 1 splice forms, both at pI 5.2) from Human epidermal desmosomes. Mab localizes Dsc1 present in - suprabasal layers of interfollicular epidermis - specific cell layers (e.g. in hair follicle root sheath) - Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).
    Aufreinigung
    Affinity Chromatography on Protein A
    Immunogen
    Synthetic peptide corresponding to sequence present within the intracellular part of Human Desmocollin 1
    Klon
    Dsc-1-U100
    Isotyp
    IgG1
    Top Product
    Discover our top product DSC1 Primärantikörper
  • Applikationshinweise
    Imunoblotting. Immunohistochemistry on frozen sections: 1: 10, 1 h at RT or overnight at 2-8C,preincubation with 0.05 - 0.2 % Triton X-100, for 5-10 min, depending on tissue type, isrecommended, Without detergent pretreatment a cytoplasmic component mightcross-react (e. g. in fibroblasts). Immunohistochemistry on paraffin-embedded sections (after microwave treatment): 1: 10, 1h at RT or overnight at 2-8C, a slight crossreactivity with a lymphocyte subpopulation isabolished by mild trypsinization after the microwave step)
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in 1 mL dist. water.
    Buffer
    PBS buffer, pH 7.4 containing 0.09 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Desmocollin 1 (DSC1)
    Andere Bezeichnung
    Desmocollin-1 (DSC1 Produkte)
    Synonyme
    DSC1 antikoerper, CDHF1 antikoerper, DG2/DG3 antikoerper, DSC1b antikoerper, DG2DG3 antikoerper, dg3 antikoerper, Dsc1a antikoerper, Dsc1b antikoerper, desmocollin 1 antikoerper, DSC1 antikoerper, Dsc1 antikoerper
    Hintergrund
    Desmocollin 1 is a component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. It may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Desmocollin 1 is linked to the keratinization of epithelial tissues.Synonyms: CDHF1, Cadherin family member 1, DG2/DG3, DSC1, Desmosomal glycoprotein 2/3
    Gen-ID
    1823
    NCBI Accession
    NP_004939
    UniProt
    Q08554
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