HCV Core Protein Antikörper (AA 70-90)

Produktnummer ABIN111759

Der Maus Monoklonal anti-HCV Core Protein Antikörper (Klon 11-B3) (ABIN111759) detektiert spezifisch HCV Core Protein in WB, EIA und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Hepatitis C Virus (HCV).

Kurzübersicht für HCV Core Protein Antikörper (AA 70-90) (ABIN111759)

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Reaktivität: Hepatitis C Virus (HCV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCV Core Protein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 11-B3

Produktdetails anti-HCV Core Protein Antikörper

Bindungsspezifität: AA 70-90

Aufreinigung: Protein G chromatography.

Immunogen: Recombinant antigen HCV (genotype 1b).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Suitable for use in ELISA (approx. 10e-6), Western blot (1: 1,000) and Immunohistochemistry(cryostat liver sections 1: 20).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL (OD280 nm, E0.1% = 1.4)

Buffer: 1X PBS, pH 7.2 with 0.01 % sodium azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HCV Core Protein

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Andere Bezeichnung: HCV Core Protein

Substanzklasse: Viral Protein

Hintergrund: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein