HCV Core Protein Antikörper (N-Term)

Produktnummer ABIN111711

Zitiert in 1 Publikation. Der Maus Monoklonal anti-HCV Core Protein Antikörper (Klon 6A1) (ABIN111711) detektiert spezifisch HCV Core Protein in EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Hepatitis C Virus (HCV).

Kurzübersicht für HCV Core Protein Antikörper (N-Term) (ABIN111711)

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Reaktivität: Hepatitis C Virus (HCV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCV Core Protein Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA)

Klon: 6A1

Produktdetails anti-HCV Core Protein Antikörper

Bindungsspezifität: AA 1-80, N-Term

Aufreinigung: Protein A chromatography

Immunogen: Recombinant protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Suitable for use in ELISA employing native viral lysates. Does not work in Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: 1X PBS, pH 7.2 with 0.01 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-HCV Core Protein Antikörper (ABIN111711)

Nattermann, Nischalke, Hofmeister, Ahlenstiel, Zimmermann, Leifeld, Weiss, Sauerbruch, Spengler: "The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells." in: The American journal of pathology, Vol. 166, Issue 2, pp. 443-53, (2005) (PubMed).

Details zu HCV Core Protein

Target: HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))

Andere Bezeichnung: HCV Core Protein

Substanzklasse: Viral Protein

Hintergrund: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein