Inducible T-Cell Co-Stimulator Ligand (ICOSLG) Antikörper

Antigen: Inducible T-Cell Co-Stimulator Ligand (ICOSLG)

Synonyme: B7H2, GL50, B7-H2, B7RP1, CD275, ICOSL, LICOS, B7RP-1, ICOS-L, KIAA0653, B7h, GI50, GL50-B, Icoslg, Ly115l, AU044799, BG071784, mKIAA0653, ICOSLG, Icosl, RGD1562791

Klonalität: Monoklonal (GM13C1)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Zell-ELISA (cELISA)

Produktnummer: ABIN108723

Produktbeschreibung

Weitere Bezeichnung: ICOS Ligand

Immunogen: GM13C1 was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the cDNA of the human ICOSL extracellular domain (AF289028). The antibody was purified by protein G affinity chromatography from cell culture supernatants

Format: Purified

Isotyp: IgG1

Klon: GM13C1

Beschreibung: The inducible co-stimulator receptor (ICOS) is a member of the CD28 receptor family that is expressed on T cells. Recently, a new ligand (ICOS ligand, ICOSL) has been identified that binds to ICOS, but not to CD28 or CTLA-4. ICOSL is constitutively expressed on monocytes, dendritic cells and B cells. Binding of ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.

Spezifität: GM13C1 recognises the extracellular domain of ICOSL transiently expressed on the cell surface of transfected BOSC cells (Fig. 1) as well as the native protein on antigen presenting cells (see reference).

Anwendungen

Applikationshinweise: GM13C1 has been tested for the use in flow cytometry and cell-ELISA. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. A titration should be performed to determine the optimal concen

Lagerung: Store the antibody at 4°C. Avoid repeated freezing and thawing.

Forschungsgebiet: Immunologie, Inflammation

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Specificity testing of GM13C1. BOSC cells were transiently transfected with an expression vector for the extracellular domain of ICOSL as well as an irrelevant protein. Expression of the constructs was tested with an anti-tag monoclonal antibody (B)

Publikationen

Publikationen: Richter G, Hayden-Ledbetter M, Irgang M et al.: "Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells." in: J Biol Chem, Vol. 276, Issue 49, pp. 45686-93, 2001 (PubMed).