anti-Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Antikörper

SIGLEC1 encodes a member of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen SIGLEC1 Kits (25) und SIGLEC1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIGLEC1 20612 Q62230
SIGLEC1 311426  
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Top anti-SIGLEC1 Antikörper auf

Showing 10 out of 233 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Ratte FITC FACS 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
627,00 €
Maus Ratte Unkonjugiert FACS, IHC (fro), IF 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
473,00 €
Maus Ratte Biotin IHC (fro)   0.2 mg Anmelden zum Anzeigen 7 bis 9 Tage
583,00 €
Maus Ratte PE FACS 100 Tests Anmelden zum Anzeigen 3 bis 4 Tage
260,00 €
Human Maus Unkonjugiert FACS, IHC (fro), IHC (p), in vitro, IHC, RIA, ELISA, WB Immunohistochemistry-Paraffin: Sialoadhesin Antibody (HSn 7D2) [ABIN153421] - IHC staining of Sialoadhesin in human spleen using DAB with hematoxylin counterstain. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Maus Ratte Unkonjugiert FACS, IHC (fro)   0.2 mg Anmelden zum Anzeigen 7 bis 9 Tage
528,00 €
Maus Ratte Unkonjugiert FACS, WB Detection of Siglec-1/CD169 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Mouse Siglec-1/CD169 Monoclonal Antibody. Detection of Mouse Siglec-1/CD169 by Western Blot. Western blot shows lysates of mouse splenocytes. PVDF Membrane was probed with 1 ug/mL of Mouse Siglec-1/CD169 Monoclonal Antibody. This experiment was conducted under non-reducing conditions. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
250,00 €
Maus Ratte FITC FACS, IF   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Human Maus FITC FACS   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
418,00 €
Human Kaninchen Unkonjugiert IHC (p) 7 mL Anmelden zum Anzeigen 6 bis 8 Tage
418,00 €

SIGLEC1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SIGLEC1 Antikörper

  1. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für FACS, IF - ABIN118291 : Kraal, Janse: Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody. in Immunology 1986 (PubMed)
    Zeige alle 12 Referenzen für 118291

  2. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für FACS - ABIN317444 : Crocker, Kelm, Dubois, Martin, McWilliam, Shotton, Paulson, Gordon: Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. in The EMBO journal 1991 (PubMed)
    Zeige alle 10 Referenzen für 317444

  3. Human Monoclonal SIGLEC1 Primary Antibody für FACS, IHC (fro) - ABIN153421 : Hartnell, Steel, Turley, Jones, Jackson, Crocker: Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. in Blood 2001 (PubMed)
    Zeige alle 10 Referenzen für 153421

  4. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für FACS, IHC (fro) - ABIN317446 : Kaisho, Takeda, Tsujimura, Kawai, Nomura, Terada, Akira: IkappaB kinase alpha is essential for mature B cell development and function. in The Journal of experimental medicine 2001 (PubMed)
    Zeige alle 10 Referenzen für 317446

  5. Human Monoclonal SIGLEC1 Primary Antibody für FACS - ABIN316948 : Kirchberger, Majdic, Steinberger, Blüml, Pfistershammer, Zlabinger, Deszcz, Kuechler, Knapp, Stöckl: Human rhinoviruses inhibit the accessory function of dendritic cells by inducing sialoadhesin and B7-H1 expression. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Zeige alle 2 Referenzen für 316948

  6. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für FACS, WB - ABIN4899472 : Honke, Shaabani, Merches, Gassa, Kraft, Ehrhardt, Häussinger, Löhning, Dittmer, Hengel, Recher, Lang, Lang: Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses. in European journal of immunology 2016 (PubMed)
    Zeige alle 2 Referenzen für 4899472

  7. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für IHC (fro) - ABIN118290 : Movita, Kreefft, Biesta, van Oudenaren, Leenen, Janssen, Boonstra: Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages. in Journal of leukocyte biology 2012 (PubMed)
    Zeige alle 2 Referenzen für 118290

  8. Mouse (Murine) Monoclonal SIGLEC1 Primary Antibody für FACS - ABIN4896153 : Lu, Chen, Rong, Yang, Li, Xu, Yu, Wang, Zhang, Shi, Chen: LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. in Nature communications 2016 (PubMed)

Weitere Antikörper gegen SIGLEC1 Interaktionspartner

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Interaktionspartner

  1. CD169(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (zeige CD8A Antikörper)(+) T-cell exhaustion and immunopathology.

  2. Although CD169 participates in the immune response to tumour antigen and appears to be a positive prognostic marker for human cancers, its role in modulating melanoma growth and metastasis is less clear.

  3. Inhibition of Siglec-1 can prevent atherosclerotic lesion formation by suppress monocytes-endothelial cells adhesion and macrophages accumulation.

  4. Data show that knockdown of sialic acid binding Ig-like lectin 1 (siglec-1) in RAW 264.7 macrophage resulted in inhibiting the production of transforming growth factor beta 1 (TGF-beta1 (zeige TGFB1 Antikörper)) production.

  5. Viral infection significantly upregulated Siglec1 expression in mouse macrophages in an IFN/JAK (zeige JAK3 Antikörper)/STAT1 (zeige STAT1 Antikörper) pathway-dependent manner.

  6. Siglec-1 is a key receptor for macrophage/lymphocyte trans-infection of surface-bound virions, and the N-acyl side chain of sialic acid is a critical determinant for the Siglec-1/MLV interaction.

  7. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread.

  8. CD169(+) monocytes and macrophages have a critical role in preventing excessive inflammation in renal ischemia-reperfusion injury by downregulating intercellular adhesion molecule-1 (zeige ICAM1 Antikörper) expression on vascular endothelial cells.

  9. results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses

  10. Sialoadhesin is critical for macrophages to phagocytose and clear the sialylated pathogen group B Streptococcus.

Human Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Interaktionspartner

  1. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid-binding immunoglobulin-like lectin.

  2. High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A (zeige TRIM21 Antikörper) indicates an enhanced risk for autoimmune congenital heart block development.

  3. These data demonstrate a prominent role for Siglec-1 in the internalization of HIV-1 to the virus-containing compartment in infected monocyte-derived macrophages

  4. These findings suggest that CD169+ macrophages in RLNs might be a useful marker for assessing clinical stage, including LN states, in patients with breast cancer.

  5. CD169 might act as a co-stimulatory molecule for cytotoxic T-cell activation, and could define a population of tumour-infiltrating macrophages with potential anti-tumour properties in human hepatocellular carcinoma tissues.

  6. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the lymph node sinus was a predictive factor for better clinical prognosis.

  7. Siglec-1 and Siglec-2 (zeige CD22 Antikörper) are potential biomarkers in autoimmune disease. (Review)

  8. Siglec-1 on myeloid cells could fuel novel CD4 (zeige CD4 Antikörper)(+) T-cell infections and contribute to HIV-1 dissemination in vivo.

  9. evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells

  10. Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses

Pig (Porcine) Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1) Interaktionspartner

  1. the transcription initiation site for sialoadhesin (Siglec-1), which is a porcine alveolar macrophage-specific gene, was determined by 5' rapid amplification of cDNA end.

  2. Fusion protein of sialoadhesin and domains 5-9 of CD163 (zeige CD163 Antikörper) receptors blocked the respiratory syndrome virus infection.

  3. European genotype porcine reproductive and respiratory syndrome virus inhibits porcine alveolar macrophages phagocytosis in vitro, through the interaction with its internalization receptor sialoadhesin.

  4. After infection, PRRSV viremia in SIGLEC1(-/-) pigs followed the same course as in SIGLEC1(-/+) and SIGLEC1(+/+) littermates. The absence of SIGLEC1 had no effect on other aspects of PRRSV infection, including disease course and histopathology.

  5. Endodomain-deletion mutants of sialoadhesin promoted porcine reproductive and respiratory syndrome virus infection less efficiently.

  6. ). These results provided fundamental evidence for CD163 (zeige CD163 Antikörper) and SN as two functional candidate genes affecting immunity in pigs.

  7. effect of antibody binding to pSn on macrophage viability, phagocytosis of microspheres, uptake and processing of soluble antigens, reactive oxygen/nitrogen species production, MHC I and MHC II cell surface expression and cytokine production

  8. Porcine sialoadhesin (CD169/Siglec-1) is an endocytic receptor that allows targeted delivery of toxins and antigens to macrophages.

  9. Sialoadhesin is confirmed as a PRRSV (porcine reproductive and respiratory syndrome virus)internalization receptor and is shown to interact with CD163 (zeige CD163 Antikörper) in PRRSV entry.

  10. Clear changes in the quantity of sialoadhesin(+) and CD163 (zeige CD163 Antikörper)(+) macrophages in the placentas and organs of embryos/fetuses during gestation.

SIGLEC1 Antigen-Profil

Protein Überblick

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound\; however, the full-length nature of this variant has not been determined.

Genbezeichner und Symbole assoziert mit SIGLEC1

  • sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1) Antikörper
  • sialoadhesin (LOC100345836) Antikörper
  • sialic acid binding Ig-like lectin 1, sialoadhesin (Siglec1) Antikörper
  • sialoadhesin (SIGLEC-1) Antikörper
  • CD169 Antikörper
  • dJ1009E24.1 Antikörper
  • p210 Antikörper
  • pSn Antikörper
  • SA Antikörper
  • SIGLEC-1 Antikörper
  • SIGLEC1 Antikörper
  • SN Antikörper

Bezeichner auf Proteinebene für SIGLEC1

sialoadhesin , SER , sheep erythrocyte receptor , sialic acid-binding Ig-like lectin 1 , sialic acid-binding immunoglobulin-like lectin 1 , Sialic acid-binding Ig-like lectin 1

469866 Pan troglodytes
100345836 Oryctolagus cuniculus
20612 Mus musculus
6614 Homo sapiens
311426 Rattus norvegicus
539759 Bos taurus
397623 Sus scrofa
Ausgewählte Anbieter für anti-SIGLEC1 (SIGLEC1) Antikörper
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