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Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) ELISA Kits

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen RUNX1T1 Antikörper (39) und RUNX1T1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Anti-Ratte RUNX1T1 RUNX1T1 362489  
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Katalog Nr. Reaktivität Sensitivität Bereich Menge Anbieter Lieferzeit Preis Details
Human
96 Tests Anmelden zum Anzeigen 9 bis 12 Tage
788,70 €
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96 Tests Anmelden zum Anzeigen 9 bis 12 Tage
788,70 €
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Weitere ELISA Kits für RUNX1T1 Interaktionspartner

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  2. Exon splicing patterns in the human RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 fusion gene present in acute myeloid leukemia (zeige BCL11A ELISA Kits) patients have been decoded.

  3. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (zeige RUNX1 ELISA Kits)-ETO/RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 is facilitated by interaction with the chaperonin (zeige HSPD1 ELISA Kits) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (zeige HSP70 ELISA Kits)).

  4. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  5. A substantial fraction of AML1 (zeige RUNX1 ELISA Kits)-ETO/p300 (zeige EP300 ELISA Kits) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

  6. minimal residual disease determined by RUNX1 (zeige RUNX1 ELISA Kits)/RUNX1T1 transcript levels could identify allogeneic hematopoietic stem cell transplantation t(8;21) (q22;q22) acute myeloid leukemia (zeige BCL11A ELISA Kits) patients who are at high risk for relapse, together with c-KIT (zeige KIT ELISA Kits) mutations

  7. identify a high-frequency mutation in t(8;21)/RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 acute myekoid leukemia (AML (zeige RUNX1 ELISA Kits)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 (zeige ASXL2 ELISA Kits) mutations in this unique subset of AML (zeige RUNX1 ELISA Kits)

  8. RUNX1 (zeige RUNX1 ELISA Kits)/ETO-induced DNA damage and apoptosis in human primary CD34 (zeige CD34 ELISA Kits)+ hematopoietic progenitors are rescued by activating c-Kit (zeige KIT ELISA Kits) mutations

  9. In t(8;21) acute myelogenous leukemia (AML (zeige RUNX1 ELISA Kits)), the acquisition of AML1 (zeige RUNX1 ELISA Kits)/ETO is not sufficient, and the subsequent upregulation of AML1 (zeige RUNX1 ELISA Kits)/ETO and the additional c-KIT (zeige KIT ELISA Kits) mutant signaling are critical steps for transformation into leukemic stem cells.

  10. Our data shows that upregulated of the RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 gene set maybe an important factor contributing to the etiology of ccRCC.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Data show that RUNX1 (zeige RUNX1 ELISA Kits)-ETO;c-Kit (zeige KIT ELISA Kits)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) in a fraction (51%) of reconstituted mice.

  2. Self-renewal induced by AML1 (zeige RUNX1 ELISA Kits)/ETO in primary murine progenitors was inhibited when Aes (zeige AES ELISA Kits) was decreased or absent.

  3. AML1 (zeige RUNX1 ELISA Kits)-ETO synergizes with an ICSBP (zeige IRF8 ELISA Kits) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  4. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (zeige CEBPB ELISA Kits) and a novel regulator of early adipogenesis

  5. the loss of the molecular events of AML1 (zeige RUNX1 ELISA Kits)-ETO C-terminal NCoR (zeige NCOR1 ELISA Kits)/SMRT-interacting domain transforms AML1 (zeige RUNX1 ELISA Kits)-ETO into a potent leukemogenic protein

  6. p15(Ink4b (zeige CDKN2B ELISA Kits)) loss must be accompanied by additional oncogenic changes for RUNX1 (zeige RUNX1 ELISA Kits)-ETO-associated AML (zeige RUNX1 ELISA Kits) to develop

  7. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  8. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (zeige RUNX1 ELISA Kits)-ETO

RUNX1T1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) Antikörper
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1) Antikörper
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) Antikörper
  • AML1T1 Antikörper
  • Cbfa2t1 Antikörper
  • Cbfa2t1h Antikörper
  • CDR Antikörper
  • ETO Antikörper
  • MTG8 Antikörper
  • si:ch211-232j17.1 Antikörper
  • wu:fi14b07 Antikörper
  • zgc:154044 Antikörper
  • ZMYND2 Antikörper

Bezeichner auf Proteinebene für RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPEZIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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