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Lack of DVL (zeige DVL2 Proteine) prevents NEK2 (zeige NEK2 Proteine)-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation. Increased DVL (zeige DVL2 Proteine) levels, in contrast, sequester centrosomal NEK2 (zeige NEK2 Proteine) and mimic monopolar spindle defects induced by a dominant negative version of this kinase.
These results identify USP4 (zeige USP4 Proteine) as a novel regulator of Dvl (zeige DVL2 Proteine) in Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signal and show its involvement in Wnt3a (zeige WNT3A Proteine)-induced osteoblast differentiation
Authors conclude that the planar cell polarity (PCP (zeige PRCP Proteine)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 (zeige RNF41 Proteine) acts as a negative regulator of PCP (zeige PRCP Proteine) signaling by inhibiting Dvl (zeige DVL2 Proteine) through a novel polyubiquitination mechanism.
The DEP domain of Dishevelled (zeige DVL2 Proteine) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (zeige CTNNB1 Proteine).
two mutually exclusive functions of the DEP domain in Wnt (zeige WNT2 Proteine) signal transduction - binding to Frizzled to recruit Dishevelled (zeige DVL2 Proteine) to the receptor complex, is reported.
we show that Wnt5a (zeige WNT5A Proteine) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (zeige POLR1C Proteine) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.
Data show that dishevelled (zeige DVL2 Proteine) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (zeige SFRP2 Proteine) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
Data show that receptor for activated C kinase 1 (RACK1 (zeige GNB2L1 Proteine)) interacts with Dishevelled (Dvl (zeige DVL2 Proteine)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.
TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.
Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain is stabilized upon CXXC finger 5 protein (CXXC5 (zeige CXXC5 Proteine)) binding.
Here we show that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.
The interaction of Dvl1 with Syt-1 (zeige SYT1 Proteine), which is regulated by Wnts, modulates neurotransmitter release.
findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced (zeige SQSTM1 Proteine) by selenium deficiency
These results support a novel cell-autonomous postsynaptic role for Dact1 (zeige DACT1 Proteine), in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1 (zeige DISC1 Proteine), in the formation of synapses on cortical interneuron dendrites.
we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 (zeige DVL2 Proteine) and Dvl-3 (zeige DVL3 Proteine) have a widespread distribution in both the olfactory epithelium and olfactory bulb .
Fuzzy appears to control subcellular localization of the core PCP (zeige BMP1 Proteine) protein Dishevelled (zeige DVL2 Proteine), recruiting it to Rab8 (zeige RAB8A Proteine)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (zeige BMP1 Proteine) signaling
A Wnt5a--> Dvl PCP signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Findings indicate that Daple interacts with Dishevelled (zeige DVL2 Proteine) to direct the Dishevelled (zeige DVL2 Proteine)/protein kinase (zeige CDK7 Proteine) lambda protein complex to activate Rac (zeige AKT1 Proteine), which in turn mediates the non-canonical Wnt (zeige WNT2 Proteine) signalling pathway required for cell migration.
The antagonistic functions of Vangl2 (zeige VANGL2 Proteine) and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.
Different Dvl (zeige DVL2 Proteine) proteins (Dvl1, Dvl2 (zeige DVL2 Proteine), Dvl3 (zeige DVL3 Proteine)) and the composition of dishevelled (zeige DVL2 Proteine)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Proteine) signaling in Xenopus gastrulation.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
DSH homolog 1
, dishevelled 1 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 1
, segment polarity protein dishevelled homolog DVL-1
, dishevelled 1
, dishevelled, dsh homolog 2, like