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Redox-sensitive activation of p38 MAPK (zeige MAPK14 Proteine)/HSP27 (zeige HSPB1 Proteine) pathway or ERK1/2 in endothelial cells requires CaMKII
In FHC (zeige FTH1 Proteine)-linked TnT (zeige TNNI1 Proteine)-mutated hearts, RyR2 is susceptible to CaMKII-mediated phosphorylation, presumably because of a mutation-linked increase in diastolic [Ca(2 (zeige CA2 Proteine)+)]i, causing aberrant Ca(2 (zeige CA2 Proteine)+) release leading to lethal arrhythmia.
astrocytic IL-17A (zeige IL17A Proteine) plays important roles in the maintenance of neuropathic pain through CaMKII/CREB (zeige CREB1 Proteine) signaling pathway in spinal cord.
Wip1 (zeige PPM1D Proteine) phosphatase plays a vital role in regulating hippocampal synaptic plasticity by modulating the phosphorylation of CaMKII.
CaMKIIgamma-deficient macrophages and atherosclerotic lesions lacking myeloid CaMKIIgamma had increased expression of the transcription factor ATF6 (zeige ATF6 Proteine).
Destabilization of PGC1a is attributable to decreased p38 MAPK (zeige MAPK14 Proteine) activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2 (zeige CA2 Proteine)+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 (zeige CAPN3 Proteine) knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige SLC25A20 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige SLC25A20 Proteine).
In young mice, 30% of adult CaMKIIalpha expression is sufficient for normal long-term potentiation in the hippocampus and cerebral cortex.
Findings demonstrate that Thr286 phosphorylation of CaMKII plays an important role in induction of long-term potentiation (LTP (zeige SCP2 Proteine)) by integrating Ca(2 (zeige CA2 Proteine)+) signals, and it greatly promotes, but is dispensable for, the activation of CaMKII and LTP (zeige SCP2 Proteine).
The present study demonstrates, for the first time, that ROS (zeige ROS1 Proteine)-dependent activation of CaMKII mediates altered Ca2 (zeige CA2 Proteine)+ handling and contractile dysfunction observed in the setting of sepsis.
Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 (zeige ETV1 Proteine) orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum.
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige CA2 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige CA2 Proteine).
oxidative stress activated the TRPM2 (zeige CLU Proteine)-CaMKII cascade to further induce intracellular ROS (zeige ROS1 Proteine) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
CKIalpha (zeige CSNK1A1 Proteine)-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle.
Demonstrate that calcium/CaMKIIgamma/AKT (zeige AKT1 Proteine) signaling can regulate apoptosis and autophagy simultaneously in colorectal cancer cells.
Dysfunction in CaMKII-based signaling has been linked with a host of cardiovascular phenotypes including heart failure and arrhythmia, and CaMKII levels are elevated in human and animal disease models of heart disease.
Inhibition of CaMKII activity results in an upregulation of CaMKIV (zeige CAMK4 Proteine) mRNA and protein in leukemia cell lines.
CAMKIIgamma, HSP70 (zeige HSP70 Proteine) and HSP90 (zeige HSP90 Proteine) transcripts are differentially expressed in chronic myeloid leukemia (zeige BCL11A Proteine) cells from patients with resistant mutated disease.
CaMKII-dependent microtube polymerization may be responsible for the enhanced uptake of PEI/ON complexes in A549 cells under oxidative stress conditions.
Our data suggest that berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
, calcium/calmodulin-dependent protein kinase type II subunit gamma
, calcium/calmodulin-dependent protein kinase II beta
, calcium/calmodulin-dependent protein kinase II gamma
, CaMK II
, caM kinase II subunit alpha
, caMK-II subunit alpha
, calcium/calmodulin-dependent protein kinase type II subunit alpha
, caMK-II subunit gamma
, Ca2+/calmodulin-dependent protein kinase II
, caM kinase II subunit gamma
, caM-kinase II gamma chain
, calcium/calmodulin-dependent protein kinase type II gamma chain