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These findings indicate that the CaMKII-mediated GluA1 (zeige GRIA1 Proteine) phosphorylation of S567 and S831 is critical for P2X2 (zeige P2RX2 Proteine)-mediated AMPAR internalization and ATP-driven synaptic depression.
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture.
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige CA2 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige CA2 Proteine).
oxidative stress activated the TRPM2 (zeige CLU Proteine)-CaMKII cascade to further induce intracellular ROS (zeige ROS1 Proteine) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential
CKIalpha (zeige CSNK1A1 Proteine)-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII gamma and delta may have negative roles in the HCV life cycle.
Demonstrate that calcium/CaMKIIgamma/AKT (zeige AKT1 Proteine) signaling can regulate apoptosis and autophagy simultaneously in colorectal cancer cells.
Dysfunction in CaMKII-based signaling has been linked with a host of cardiovascular phenotypes including heart failure and arrhythmia, and CaMKII levels are elevated in human and animal disease models of heart disease.
Inhibition of CaMKII activity results in an upregulation of CaMKIV (zeige CAMK4 Proteine) mRNA and protein in leukemia cell lines.
CAMKIIgamma, HSP70 (zeige HSP70 Proteine) and HSP90 (zeige HSP90 Proteine) transcripts are differentially expressed in chronic myeloid leukemia (zeige BCL11A Proteine) cells from patients with resistant mutated disease.
CaMKII-dependent microtube polymerization may be responsible for the enhanced uptake of PEI/ON complexes in A549 cells under oxidative stress conditions.
Redox-sensitive activation of p38 MAPK (zeige MAPK14 Proteine)/HSP27 (zeige HSPB1 Proteine) pathway or ERK1/2 in endothelial cells requires CaMKII
RGS6 (zeige RGS6 Proteine) and oxidized CaMKIIdelta together function as novel critical upstream modulators of Notch (zeige NOTCH1 Proteine) signaling required for normal cardiovascular development and embryo survival.
CaMKIIgamma-deficient macrophages and atherosclerotic lesions lacking myeloid CaMKIIgamma had increased expression of the transcription factor ATF6 (zeige ATF6 Proteine).
A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC (zeige SLC25A20 Proteine)) development, thereby providing a potential new therapeutic target for CAC (zeige SLC25A20 Proteine).
Data indicate that combined cardiomyocyte-specific deletion of CaM Kinase II CaMKIIdelta/gamma does not affect ischemia/reperfusion (I/R) injury.
Cardiac CaM Kinase II genes delta and gamma contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.
CaMKIIdeltagamma couples noncanonical Wnt signaling to histone deacetylase 4 and myosin enhancer factor 2.
Camk2g-deficient obese mice have higher nuclear ATF6 (zeige ATF6 Proteine) levels, and silencing ATF6 (zeige ATF6 Proteine) in these mice lowers p58IPK (zeige DNAJC3 Proteine) and suppresses insulin (zeige INS Proteine)-induced p-Akt (zeige AKT1 Proteine).
Phosphorylation at specific PEVK/titin (zeige TTN Proteine) N2B-unique sequence sites was decreased in CAMK2g/d double knockout mice.
The CamkIIgamma isoform is poorly expressed in synaptic sites. Its activity is critical for receptor recycling and may provide a mechanism by which the postsynaptic acetylcholine receptor (zeige CHRNB1 Proteine) density is maintained at the neuromuscular junction in vivo.
CamKIIgamma3 isoform plays a necessary and sufficient role in transducing the oscillatory Ca(2 (zeige CA2 Proteine)+) signal into cell cycle resumption, but not into cortical granule release
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.
caMK-II subunit gamma
, calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
, calcium/calmodulin-dependent protein kinase type II subunit gamma
, caM kinase II subunit gamma
, caM-kinase II gamma chain
, calcium/calmodulin-dependent protein kinase type II gamma chain
, calcium/calmodulin-dependent protein kinase II gamma
, Ca2+/calmodulin-dependent protein kinase II
, CaMK II
, CaM kinase II gamma B
, CaM kinase II gamma C-1
, CaM kinase II gamma C-2
, CaM kinase II gamma G-1
, CaM kinase II gamma G-2
, CaM kinase II gamma J