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Human S100A8 Protein expressed in Wheat germ - ABIN1319072
Maiseyeu, Badgeley, Kampfrath, Mihai, Deiuliis, Liu, Sun, Parthasarathy, Simon, Croce, Rajagopalan: In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles. in Arteriosclerosis, thrombosis, and vascular biology 2012
Show all 5 Pubmed References
Mouse (Murine) S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN5569738
Schneider, Schenone, Ferreira, Kramann, Joyce, Hartigan, Beier, Brümmendorf, Germing, Platzbecker, Büsche, Knüchel, Chen, Waters, Chen, Chu, Novina, Lindsley, Carr, Ebert: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. in Nature medicine 2016
Human S100A8 Protein expressed in Escherichia coli (E. coli) - ABIN2181719
Gruda, Ruggeberg, OSullivan, Guliashvili, Scheirer, Golobish, Capponi, Chan: Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads. in PLoS ONE 2017
Studies indicate S100A8 as the most overexpressed gene, and the cell cycle pathway as the most promising biomarker and therapeutic target for relapsed childhood B-acute lymphoblastic leukemia (B-ALL).
Low S100A8 expression is associated with head and neck neoplasms.
Report role of fecal calprotectin assay in the diagnosis and management of inflammatory bowel disease.
S100A8 and S100A9 (zeige S100A9 Proteine) aggravate Coxsackievirus B3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies.
Data suggest that fecal calprotectin may be a potential biomarker to identify patients with ankylosing spondylitis (AS) at risk of developing inflammatory bowel disease (IBD).
Elevated S100A8 and S100A9 (zeige S100A9 Proteine) gene expression in SP-infected HMEECs and in the middle ear mucosa of OM, minor co-localized with neutrophil markers suggests that middle ear epithelial cell secretion of S100A8 and S100A9 (zeige S100A9 Proteine) may play a role in the pathogenesis of recurrent and chronic OM
results of this study support an additional role of calprotectin in assessing inflammatory activity in patients with RA
Data show that E3 ubiquitin ligase (zeige MUL1 Proteine) HRD1 (HRD1 (zeige SYVN1 Proteine)) decreased the protein level of S100A8 through ubiquitination.
High S100A8 expression is associated with glioblastoma.
This study implicates S100A8 and S100A9 (zeige S100A9 Proteine) as important mediators of tumor cell aggressiveness, and highlights the therapeutic potential of S100A8 and S100A9 (zeige S100A9 Proteine) for interference of metastasis.
Data suggest that up-regulation of S100A8 and S100A9 (zeige S100A9 Proteine) is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Study verified porcine calprotectin (S100A8/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
theses findings reveal unexpected gene expression differences between WT and KO mice at a young age (in the absence of physiological stress), and address the hypothesis that Mrp8 and Mrp14 (zeige S100A9 Proteine) accumulation promotes age-related inflammation
Neutrophil-derived S100A8/A9 promotes thrombocytosis in diabetic mice
Perinatal alarmins S100A8 and S100A9 (zeige S100A9 Proteine) specifically altered MyD88 (zeige MYD88 Proteine)-dependent proinflammatory gene programs. S100 programming prevented hyperinflammatory responses without impairing pathogen defense. TRIF (zeige RNF138 Proteine)-adaptor-dependent regulatory genes remained unaffected by perinatal S100 programming and responded strongly to lipopolysaccharide, but were barely expressed.
S100a8 upregulation triggers NF-kappaB (zeige NFKB1 Proteine) signal pathway through RAGE (zeige AGER Proteine) and TLR4 (zeige TLR4 Proteine), in response to laser-induced dermis wound healing.
Although MRP-8/-14 expression is highly increased in experimental, these proteins do not contribute to the pathogenesis in the effector phase of epidermolysis bullosa acquisita and bullous pemphigoid (zeige DST Proteine).
TLR4 (zeige TLR4 Proteine), TLR2 also contributed to Mrp8-induced inflammatory response and tolerance.
S100A8 appears to play a crucial role in the activation of the TLR4 (zeige TLR4 Proteine)/MD-2 (zeige LY96 Proteine) pathway and the promotion of a tumor growth-enhancing immune microenvironment.
Rps14 (zeige RPS14 Proteine) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8-S100A9 (zeige S100A9 Proteine) expression, leading to a p53 (zeige TP53 Proteine)-dependent erythroid differentiation defect.
S100A8 is primarily produced from CXCR2 (zeige CXCR2 Proteine)-expressing CD11b (zeige ITGAM Proteine)(+)Gr-1 (zeige GSR Proteine)(high) cells, and it upregulates TNF-alpha (zeige TNF Proteine) production in CD11b (zeige ITGAM Proteine)(+)F4/80(+) cells through cellular cross-talk, which is an important mechanism in the development of Nonalcoholic fatty liver disease
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
, S100 calcium-binding protein A8 (calgranulin A)
, calgranulin A
, calprotectin L1L subunit
, cystic fibrosis antigen
, leukocyte L1 complex light chain
, migration inhibitory factor-related protein 8
, protein S100-A8
, urinary stone protein band A
, S100 calcium binding protein A8 (calgranulin A)
, S100 calcium binding protein A8
, S100 calcium-binding protein A8
, neutrophil cytosolic 7 kDa protein
, chemotactic S100 protein
, chemotactic cytokine CP-10
, pro-inflammatory S100 cytokine
, macrophage migration inhibitory factor-related protein-8