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SAA1 (zeige SAA1 Proteine)/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR (zeige LDLR Proteine) knockout mice.
CE/J mice possess functional Saa1 (zeige SAA1 Proteine) and Saa2 (zeige SAA1 Proteine) genes with identical amino acid sequence.
Its gene hold broader diversity and greater complexity and these characteristics were likely attained through gene duplication and repeated gene conversion events in the Mus (zeige TRPV6 Proteine) lineage.
The absence of endogenous SAA1.1 and 2.1 does not affect atherosclerotic lipid deposition in apolipoprotein E (zeige APOE Proteine)-deficient mice fed either normal or Western diets.
High level SAA (zeige SAA1 Proteine) expression induced amyloidosis in all mice after a short, slightly variable delay.
Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag (zeige STMN1 Proteine) phase contrary to the highly amyloidogenic non-pathogenic SAA2.2
These results suggest that the carboxy terminus of SAA (zeige SAA1 Proteine), which is highly conserved among SAA (zeige SAA1 Proteine) sequences in all vertebrates, might play important structural roles, including modulating the folding, oligomerization, misfolding, and fibrillation of SAA (zeige SAA1 Proteine).(Saa2 (zeige SAA1 Proteine))
The ability of SAA2.2 to form different oligomeric species in vitro along with its marginal stability, suggest that the structure of SAA (zeige SAA1 Proteine) might be modulated in vivo to form different biologically relevant species.
SAA (zeige SAA1 Proteine) does not impact High Density Lipoprotein levels, apoA-I (zeige APOA1 Proteine) clearance, or High Density Lipoprotein size
Many functional and pathological roles attributed to serum amyloid A may rely on its precarious structure, modulated by its interaction with ligands under homeostasis conditions and during the acute phase response.
The prevalence of the SAA2 (zeige SAA1 Proteine) polymorphisms (rs 2445174 and rs2468844) did not differ significantly between the groups of ankylosing spondylitis patients with and without amyloidosis.
successful quantification of SAA2 (zeige SAA1 Proteine) in crude serum by MRM, for the first time, shows that SAA2 (zeige SAA1 Proteine) can be a good biomarker for the detection of lung cancers.
Data show that both rs12218 of the SAA1 gene and rs2468844 of SAA2 gene are associated with carotid IMT in healthy Han Chinese subjects.
The glucocorticoid response element of the SAA2 (zeige SAA1 Proteine) promoter is dysfunctional compared to that of SAA1 (zeige SAA1 Proteine), hence glucocorticoids are unable to enhance the cytokine-driven transcriptional activity of SAA2 (zeige SAA1 Proteine).
saa2 (zeige SAA1 Proteine) is regulated by tumor necrosis factor-alpha (zeige TNF Proteine), interleukin-6 (zeige IL6 Proteine), and glucocorticoids in hepatic and epithelial cells.
SAA1a/a genotype is one genetic factor that confers a significant risk for amyloidosis in the Turkish FMF (zeige MEFV Proteine) population but neither SAA1 (zeige SAA1 Proteine) nor SAA2 (zeige SAA1 Proteine) genotypes had a significant effect on SAA (zeige SAA1 Proteine) level.
Increased expression of SAA2 (zeige SAA1 Proteine) by adipocytes in obesity may play a critical role in local and systemic inflammation and free fatty acid production and could be a direct link between obesity and its comorbidities.
CRP (zeige CRP Proteine) and SAA (zeige SAA1 Proteine) strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.
Major acute phase reactant. Apolipoprotein of the HDL complex.
serum amyloid A2
, serum amyloid A 1
, serum amyloid A-2 protein
, serum amyloid A protein