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Human TLR9 Protein expressed in Wheat germ - ABIN1330558
Julian, Shao, Vangundy, Papenfuss, Crouser: Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. in PLoS ONE 2013
Genotyping was performed to detect -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary tuberculosis and healthy controls. The A allele of G2848A SNP in TLR9 gene was found with a marginally higher frequency among tuberculosis patients.
The TLR3 (zeige TLR3 Proteine).rs3775290 "CC" genotype was associated with hepatitis C virus chronicity, while the TLR9 gene may not play a major role in hepatitis C virus infection.
Identify both expansion of T-bet(+) B cells and production of anti-erythrocyte antibodies in ex vivo cultures of naive peripheral blood mononuclear cells exposed to P. falciprum infected erythrocyte lysates. We propose that synergistic TLR9/IFN-gammaR activation of T-bet(+) B cells is a mechanism underlying infection-induced autoimmune-like responses.
TLR9, especially TLR9/CD3 (zeige CD3 Proteine), is highly expressed in systemic sclerosis patients particularly those with diffuse cutaneous subtype and could form a potential marker for skin fibrosis and disease severity.
TLR9 Gene Polymorphism is not associated with Chronic Lymphocytic Leukemia.
TLR-9 gene rs187084 polymorphism is positively correlated with susceptibility to Osteoarthritis of Knee, especially among old people in a Chinese population.
Data showed strong interactions of toll (zeige TLR4 Proteine)-like receptors TLR2 and 4 associated with Leishmania(V.) braziliensis, while toll (zeige TLR4 Proteine)-like receptor TLR9, in contrast, a strong interaction with Leishmania (L.) amazonensis.
Studied associations of 12 single nucleotide polymorphisms (SNPs) within toll (zeige TLR4 Proteine) like receptor genes (TLR2, TLR3 (zeige TLR3 Proteine), TLR4 (zeige TLR4 Proteine), and TLR9) and genetic predisposition to newborn severe hepatitis.
TLR7 (zeige TLR7 Proteine), TLR9, and JAK2 (zeige JAK2 Proteine) genes are potential biomarkers for systemic sclerosis. High TLR7 (zeige TLR7 Proteine) expression positively correlated with the late form of disease. Decreased levels of TLR9 and JAK2 (zeige JAK2 Proteine) mRNA were found in the patient's cohort in comparison to non-SSc (zeige CYP11A1 Proteine) individuals.
TLR9 rs187084 gene polymorphism may be associated with post-bronchiolitis wheezing, and TLR10 (zeige TLR10 Proteine) rs4129009 gene polymorphism may be associated with atopy.
Plasmodium DNA induces autoreactive responses against erythrocytes by activating a population of B cells expressing CD11c and the transcription factor T-bet, which become major producers of autoantibodies that promote malarial anaemia.
Our findings suggested the collaboration of TLR2-TLR9 at least in the regulation of SARM (zeige SARM1 Proteine) expression.
High cholesterol intake exacerbated acetaminophen-induced acute liver injury via the accumulation of free cholesterol in the endolysosomes of liver sinusoidal endothelial cells. This accumulation enhanced Toll-like receptor 9 signaling via impairment of its membrane trafficking mechanism.
these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 governs the primary response and RAGE (zeige AGER Proteine) plays a distinct and cooperative function in providing a pivotal role in balancing the immune response.
this study shows that CD205 (zeige LY75 Proteine)-TLR9-IL-12 (zeige IL12A Proteine) axis contributes to CpG-induced oversensitive liver injury in Hepatitis B viral antigens transgenic mice by promoting the interaction of NKT (zeige CTSL1 Proteine) cells with Kupffer cells
The findings support a salutary role of TLR9 in some subsets of HF conditions and underline the importance for future studies on the mechanisms of TLR9 in diastolic HF.
TLR9-driven inflammation induced a Ccr2-independent expansion of functionally enhanced extramedullary myeloid progenitors that correlated with the peripheral accumulation of monocytes in both wild-type and Ccr2(-/-) mice.
TLR9 expression on B1a cells is not critical for their IgM-dependent atheroprotection.
This study establishes a correlation between TLR-3 (zeige TLR3 Proteine) and TLR-9 expression with the development of EAE. In addition, evidence of a role for the myelin peptide in targeting the innate inflammatory response to the CNS is presented.
these data demonstrate that TLR7 (zeige TLR7 Proteine)/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.
Porcine parvovirus virus infection significantly induced IL-6 (zeige IL6 Proteine) expression and this induction depended on NF-kappaB (zeige NFKB1 Proteine) activation and TLR9 signaling pathways in PK-15 cell.
TLR9 immunoreactivity is mainly detected in epithelial cells and antigen presenting cells, namely dendritic and macrophage-like cells, within the range of tissues examined. The pattern of TLR9 expression was similar in pigs of 3 weeks and 3 months of age.
These data demonstrated that TLR2, TLR3 (zeige TLR3 Proteine) and TLR9 contribute to NF-kappaB (zeige NFKB1 Proteine) activation in response to porcine epidemic diarrhea virus infection, but not RIG-I (zeige DDX58 Proteine).
expression of TLR3 (zeige TLR3 Proteine), TLR7 (zeige TLR7 Proteine) and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Moreover, the TLR9 transfectant demonstrated its usefulness for evaluation of immunostimulation by bacterial DNA through the detection of T(H)-1, T(H)-2 type cytokine induction via TLR9 signaling.
variants in the TLR1 (zeige TLR1 Proteine) gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
mRNA abundances of TLR9, TLR2, and TLR4 (zeige TLR4 Proteine) together with those of beta-defensin 5 (BNBD5 (zeige DEFB105A Proteine)), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
Toll-like receptor 9 protein