anti-TLR7 (TLR7) Antikörper

Human Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. TLR7 upregulation has a role in liver cancer cell proliferation involving lipid rafts

2. Study demonstrates that Hepatitis C virus (HCV) genomic RNA harbours specific sequences that initiate an anti-HCV immune response through TLR7 and TLR8 (zeige TLR8 Antikörper) in various antigen presenting cells.

3. TLR7, TLR9 (zeige TLR9 Antikörper), and JAK2 (zeige JAK2 Antikörper) genes are potential biomarkers for systemic sclerosis. High TLR7 expression positively correlated with the late form of disease. Decreased levels of TLR9 (zeige TLR9 Antikörper) and JAK2 (zeige JAK2 Antikörper) mRNA were found in the patient's cohort in comparison to non-SSc (zeige CYP11A1 Antikörper) individuals.

4. The results indicate that TLR7 up-regulation is related to Respiratory syncytial virus infection and the induction of oxidative stress and that TLR7 expression was mediated by the anti-inflammatory effects of Nrf2 (zeige GABPA Antikörper)/ARE pathway inhibitors or agonists.

5. Thus, TLR7 and TLR8 (zeige TLR8 Antikörper) might modulate different immune responses in monocytes and macrophages.

6. Positive rates of iNOS (zeige NOS2 Antikörper) in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3 (zeige TLR3 Antikörper), TLR4 (zeige TLR4 Antikörper), TLR7, TLR8 (zeige TLR8 Antikörper), NF-kappaB (zeige NFKB1 Antikörper) p65 (zeige GORASP1 Antikörper), and iNOS (zeige NOS2 Antikörper) in cervical epithelial cells were higher in CC group than in other groups.

7. Data suggest a central role of XBP1 (zeige XBP1 Antikörper) in TLR7-induced IFNalpha production and identify XBP1 (zeige XBP1 Antikörper) as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.

8. These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.

9. The present study investigated the effects of vitamin D3 on the expression of TLR3 (zeige TLR3 Antikörper), TLR7, and TLR9 (zeige TLR9 Antikörper) in Systemic lupus erythematosus patients.

10. Data suggest that IRAK4 (zeige IRAK4 Antikörper) activity regulates activation of IRF5 (zeige IRF5 Antikörper), TAK1 (zeige MAP3K7 Antikörper), and IKKB (zeige IKBKB Antikörper) in monocytes; IRAK4 (zeige IRAK4 Antikörper) activation of TAK1 (zeige MAP3K7 Antikörper)-IKKB (zeige IKBKB Antikörper)-IRF5 (zeige IRF5 Antikörper) axis leads to induction of cytokines and interferons following TLR7/TLR8 (zeige TLR8 Antikörper) stimulation. (IRAK4 (zeige IRAK4 Antikörper) = interleukin-1 receptor-associated kinase 4 (zeige IRAK4 Antikörper); IRF5 (zeige IRF5 Antikörper) = interferon regulatory factor-5 (zeige IRF5 Antikörper); TAK1 (zeige MAP3K7 Antikörper) = MAPK (zeige MAPK1 Antikörper) kinase kinase 7; IKKB (zeige IKBKB Antikörper) = I-kappa B kinase; TLR = toll (zeige TLR4 Antikörper)-like receptor)

Mouse (Murine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. conclude that VDD promotes tumor growth in the context of Smad3 (zeige SMAD3 Antikörper) disruption, potentially through regulation of TLR7 expression and beta-catenin (zeige CTNNB1 Antikörper) activation

2. activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder

3. Here, we show that under these circumstances, the Toll (zeige TLR4 Antikörper)-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 (zeige TLR3 Antikörper) ligand poly I:C or TLR9 (zeige TLR9 Antikörper) ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4 (zeige CD4 Antikörper)(+) T cells, whereas activated CD8 (zeige CD8A Antikörper)(+) T cells were dispensable

4. TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 (zeige IGF1 Antikörper) from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD (zeige TSC2 Antikörper).

5. Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.

6. results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.

7. these data demonstrate that TLR7/TLR9 (zeige TLR9 Antikörper) ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.

8. Virus infection activates endosomal NOX2 (zeige CYBB Antikörper) oxidase and restricts TLR7 signaling, and that an endosomal NOX2 (zeige CYBB Antikörper) inhibitor decreases viral pathogenicity.

9. the JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 (zeige TLR3 Antikörper) and TLR7 pathways.

10. TLR7 deficiency attenuates retinal damage in diabetic retinopathy model.

Cow (Bovine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll (zeige TLR4 Antikörper)-Like Receptors.

2. The results from this study demonstrate that expression of at least TLR3 (zeige TLR3 Antikörper), TLR7 and TLR8 (zeige TLR8 Antikörper) is stimulated upon bovine alpha-herpesvirus infection of the brain.

Horse (Equine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. The messenger RNA sequences and exon/intron structures of Toll (zeige TLR4 Antikörper)-like receptors 3, 7, and 8 were determined.

Pig (Porcine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. expression of TLR3 (zeige TLR3 Antikörper), TLR7 and TLR9 (zeige TLR9 Antikörper) in alveolar macrophages infected with different genotype 1 PRRSV strains

2. Porcine TLR7 and TLR8 (zeige TLR8 Antikörper) genes from pig lymph node tissue, were cloned and characterized.

Goat Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR (zeige UTS2R Antikörper).

Guinea Pig Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.