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anti-Human TLR7 Antikörper:
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Human Polyclonal TLR7 Primary Antibody für FACS, ICC - ABIN4360352
Palazzo, Gariboldi, Zanobbio, Dusio, Selleri, Bedoni, Balsari, Rumio: Cross-talk among Toll-like receptors and their ligands. in International immunology 2008
Show all 53 Pubmed References
Human Polyclonal TLR7 Primary Antibody für FACS, ICC - ABIN4360350
Kalali, Köllisch, Mages, Müller, Bauer, Wagner, Ring, Lang, Mempel, Ollert: Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 20 Pubmed References
Human Polyclonal TLR7 Primary Antibody für FACS - ABIN4360348
Xirakia, Koltsida, Stavropoulos, Thanassopoulou, Aidinis, Sideras, Andreakos: Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma. in American journal of respiratory and critical care medicine 2010
Show all 18 Pubmed References
Human Polyclonal TLR7 Primary Antibody für FACS, IHC (fro) - ABIN252541
Chen, Nagaraju, Bakay, McIntyre, Rawat, Shi, Hoffman: Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy. in Neurology 2005
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Human Polyclonal TLR7 Primary Antibody für FACS - ABIN4360345
Lee, Wu, Lee, Chuang, Katakura, Liu, Chan, Tawatao, Chung, Shen, Cottam, Lai, Raz, Carson: Activation of anti-hepatitis C virus responses via Toll-like receptor 7. in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Polyclonal TLR7 Primary Antibody für FACS - ABIN4360344
Wong, Cheung, Ip, Lam: Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. in American journal of respiratory cell and molecular biology 2007
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Human Monoclonal TLR7 Primary Antibody für CyTOF, FACS - ABIN4360357
Lehmann, Krüger, Park, Derkow, Rosenberger, Baumgart, Trimbuch, Eom, Hinz, Kaul, Habbel, Kälin, Franzoni, Rybak, Nguyen, Veh, Ninnemann, Peters, Nitsch, Heppner, Golenbock, Schott, Ploegh, Wulczyn et al.: An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. ... in Nature neuroscience 2012
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Human Polyclonal TLR7 Primary Antibody für IHC (fro), FACS - ABIN537535
Palladino, Johnson, Gupta, Chapman, Ojha: Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. in Biology of reproduction 2007
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Human Monoclonal TLR7 Primary Antibody für FACS - ABIN4897510
Ma, Ni, Zhang, Zhang, Wu, Atia, Thayer, Moorman, Yao: PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection. in Immunology 2011
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Human Polyclonal TLR7 Primary Antibody für IHC (p), WB - ABIN4360334
Tengroth, Millrud, Kvarnhammar, Kumlien Georén, Latif, Cardell: Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. in PLoS ONE 2014
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high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans.
Long Noncoding RNA Signatures Induced by Toll-Like Receptor 7 and Type I Interferon Signaling in Activated Human Plasmacytoid Dendritic Cells
in this paper, the activation of TLR7 is proposed and discussed as the third signal for the robust generation of spontaneous-germinal centers B cells in systemic lupus erythematosus
Modulation of TLR7 signaling pathways and decrease of macrophage-mediated inflammation might be potential therapeutic strategies in LMNA-RM management.
type I IFN and TLR7-mediated IFN-alpha production were involved in a vicious cycle, causing hyper production of IFN-alpha by pDCs during the pathogenic processes of systemic lupus erythematosus.
The single-nucleotide polymorphism rs179008 (GLn11Leu) in TLR7 was significantly more prevalent in healthy females than in those with chronic hepatitis B virus infection (42 versus 28%), suggesting that in females it may offer protection from chronic infection.
This study revealed the plausible role of TLR7 rs3853839 SNP in systemic lupus erythematosus in Egyptian women.
The TLR7 activation-induced osteoclastogenesis in RA through direct induction of osteoclast differentiation from its precursors and up-regulation of RANKL production in RA synovial fibroblasts.
In gastro-esophageal junction adenocarcinoma subgroup, only the mRNA expression of TLR-7 and protein concentrations of TLR-4, TLR-7 and TLR-9 were significantly higher in tumors than in normal mucosa (p < 0.05).
The C allele is protective of chronic hepatitis C virus (HCV) infection in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
these results indicated that TLR7 polymorphisms play an important role in disease susceptibility and the progression of chronic hepatitis B infections in Chinese adults, and may partly explain the high incidence of HBV related diseases in Chinese men.
Testing permutations of the nucleobase at ribose-methylated position 54 suggested that the extent of silencing and antagonism of the TLR7 response was governed by hydrogen patterns and lipophilic interactions of the nucleobase. The results identify a new immune-modulatory endogenous RNA modification that limits TLR7 activation by RNA
Study of TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs in chronic hepatitis C (HCV) Egyptian patient cohort revealed that only heterozygous CT genotype of TLR3 rs3775290 may be a susceptibility risk factor for chronic HCV infection and the homozygous CC and the combined CC-AT-GA female genotypes may be protective.
Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NF-kappaB/c-Myc signaling in female esophageal carcinoma.
TLR7 agonist promoted CD8(+) T cells function from breast cancer patients
In female patients with HIV/HCV-coinfection, HIV-monoinfection, chronic hepatitis C, and healthy individuals the TLR7 gene Leu polymorphic allele is recorded by 2.1-3.6 times more frequently than in male patients
Results of a study compared Spanish psoriasis patient and healthy controls showed significant associations between functional TLR3, TLR7 and TLR9 single nucleotide polymorphisms and psoriatic arthritis, earlier disease onset and a greater risk for psoriasis.
This study demonstrated that the rs3853839 C allele of the TLR-7 gene was also a risk factor for severe Hand, Foot, and Mouth Disease (HFMD) in both male and female patients. The A allele at the rs179019 locus of the TLR-7 gene was not risk factors for severe HFMD in either male or female patients.
SOCS1/3-mediated degradation of IFN regulatory factor 7 directly regulates TLR7 signaling and type I IFN production in pDCs.
Systemic lupus erythematosus CXCR5(-) CD11c(+) B cells (DN2) are hyper-responsive to Toll-like receptor-7 signaling.
increased TLR7 signaling caused by increased expression of TLR7 and its endogenous ligand let-7b may contribute to the enhanced inflammatory response associated with alcoholic hepatitis
The critical roles MMP10 plays in controlling macrophage activation to indicate that the development of immune tolerance to TLR7 ligand is dependent on this macrophage-derived proteinase.
A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs.
model of systemic autoimmunity that depends on T cell detection of a membrane-bound OVA fusion protein expressed by MHC class II+ cells, expression of TLR7, expression of the type I IFN receptor, and loss of expression of TLR9, with a high frequency of OVA-specific Tbet+, IFN-gamma+, and FasL-expressing Th1 cells as well as autoantibody-producing B cells
Gal-9 inhibits the phenotypic maturation of pDCs and B cells and abrogates their ability to mount cytokine responses to TLR7/TLR9 ligands.
High TLR7 expression is associated with Nonalcoholic Steatohepatitis.
data demonstrate an interplay between TLR7 signaling and unfolded protein response and indicate that Pin1 modulates these processes during eosinophil development
TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection.
The activation of TLR8, TLR7, or TLR3 results in dendritic shortening, and TLR7 and TLR3 but not TLR8 also control axonal growth.
Development of TLR7-driven lupus nephritis was not abolished by the deletion of IL-1beta.
Study data clearly demonstrate a specific role for Tlr7 signaling in local and systemic natural killer cell activation following respiratory Influenza A virus (IAV) infection despite the presence of redundant innate IAV-recognition pathways.
Th17-associated cytokines through NF-kappaB and toll-like receptor 7 (TLR7) signaling.
Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC).
The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia.
TLR7 deletion reduces atherosclerosis in apolipoprotein E-deficient mice.
SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells
Up-regulation of TLR7 could eliminate intracellular Mtb through autophagy
conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation
activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder
On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll-Like Receptors.
The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
The messenger RNA sequences and exon/intron structures of Toll-like receptors 3, 7, and 8 were determined.
expression of TLR3, TLR7 and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 genes from pig lymph node tissue, were cloned and characterized.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long