anti-TLR7 (TLR7) Antikörper

Human Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. high-resolution mass cytometry analysis reveals a delay of cytokines production after TLR4 or TLR7/8 engagements in HIV-1 infected humans.

2. Long Noncoding RNA Signatures Induced by Toll-Like Receptor 7 and Type I Interferon Signaling in Activated Human Plasmacytoid Dendritic Cells

3. in this paper, the activation of TLR7 is proposed and discussed as the third signal for the robust generation of spontaneous-germinal centers B cells in systemic lupus erythematosus

4. Modulation of TLR7 signaling pathways and decrease of macrophage-mediated inflammation might be potential therapeutic strategies in LMNA-RM management.

5. type I IFN and TLR7-mediated IFN-alpha production were involved in a vicious cycle, causing hyper production of IFN-alpha by pDCs during the pathogenic processes of systemic lupus erythematosus.

6. The single-nucleotide polymorphism rs179008 (GLn11Leu) in TLR7 was significantly more prevalent in healthy females than in those with chronic hepatitis B virus infection (42 versus 28%), suggesting that in females it may offer protection from chronic infection.

7. This study revealed the plausible role of TLR7 rs3853839 SNP in systemic lupus erythematosus in Egyptian women.

8. The TLR7 activation-induced osteoclastogenesis in RA through direct induction of osteoclast differentiation from its precursors and up-regulation of RANKL production in RA synovial fibroblasts.

9. In gastro-esophageal junction adenocarcinoma subgroup, only the mRNA expression of TLR-7 and protein concentrations of TLR-4, TLR-7 and TLR-9 were significantly higher in tumors than in normal mucosa (p < 0.05).

10. The C allele is protective of chronic hepatitis C virus (HCV) infection in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.

11. these results indicated that TLR7 polymorphisms play an important role in disease susceptibility and the progression of chronic hepatitis B infections in Chinese adults, and may partly explain the high incidence of HBV related diseases in Chinese men.

12. Testing permutations of the nucleobase at ribose-methylated position 54 suggested that the extent of silencing and antagonism of the TLR7 response was governed by hydrogen patterns and lipophilic interactions of the nucleobase. The results identify a new immune-modulatory endogenous RNA modification that limits TLR7 activation by RNA

13. Study of TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs in chronic hepatitis C (HCV) Egyptian patient cohort revealed that only heterozygous CT genotype of TLR3 rs3775290 may be a susceptibility risk factor for chronic HCV infection and the homozygous CC and the combined CC-AT-GA female genotypes may be protective.

14. Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NF-kappaB/c-Myc signaling in female esophageal carcinoma.

15. TLR7 agonist promoted CD8(+) T cells function from breast cancer patients

16. In female patients with HIV/HCV-coinfection, HIV-monoinfection, chronic hepatitis C, and healthy individuals the TLR7 gene Leu polymorphic allele is recorded by 2.1-3.6 times more frequently than in male patients

17. Results of a study compared Spanish psoriasis patient and healthy controls showed significant associations between functional TLR3, TLR7 and TLR9 single nucleotide polymorphisms and psoriatic arthritis, earlier disease onset and a greater risk for psoriasis.

18. This study demonstrated that the rs3853839 C allele of the TLR-7 gene was also a risk factor for severe Hand, Foot, and Mouth Disease (HFMD) in both male and female patients. The A allele at the rs179019 locus of the TLR-7 gene was not risk factors for severe HFMD in either male or female patients.

19. SOCS1/3-mediated degradation of IFN regulatory factor 7 directly regulates TLR7 signaling and type I IFN production in pDCs.

20. Systemic lupus erythematosus CXCR5(-) CD11c(+) B cells (DN2) are hyper-responsive to Toll-like receptor-7 signaling.

Mouse (Murine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. increased TLR7 signaling caused by increased expression of TLR7 and its endogenous ligand let-7b may contribute to the enhanced inflammatory response associated with alcoholic hepatitis

2. in this paper, the activation of TLR7 is proposed and discussed as the third signal for the robust generation of spontaneous-germinal centers B cells in systemic lupus erythematosus

3. The critical roles MMP10 plays in controlling macrophage activation to indicate that the development of immune tolerance to TLR7 ligand is dependent on this macrophage-derived proteinase.

4. A critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs.

5. model of systemic autoimmunity that depends on T cell detection of a membrane-bound OVA fusion protein expressed by MHC class II+ cells, expression of TLR7, expression of the type I IFN receptor, and loss of expression of TLR9, with a high frequency of OVA-specific Tbet+, IFN-gamma+, and FasL-expressing Th1 cells as well as autoantibody-producing B cells

6. Gal-9 inhibits the phenotypic maturation of pDCs and B cells and abrogates their ability to mount cytokine responses to TLR7/TLR9 ligands.

7. High TLR7 expression is associated with Nonalcoholic Steatohepatitis.

8. data demonstrate an interplay between TLR7 signaling and unfolded protein response and indicate that Pin1 modulates these processes during eosinophil development

9. TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection.

10. The activation of TLR8, TLR7, or TLR3 results in dendritic shortening, and TLR7 and TLR3 but not TLR8 also control axonal growth.

11. Development of TLR7-driven lupus nephritis was not abolished by the deletion of IL-1beta.

12. Study data clearly demonstrate a specific role for Tlr7 signaling in local and systemic natural killer cell activation following respiratory Influenza A virus (IAV) infection despite the presence of redundant innate IAV-recognition pathways.

13. Th17-associated cytokines through NF-kappaB and toll-like receptor 7 (TLR7) signaling.

14. Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC).

15. The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia.

16. TLR7 deletion reduces atherosclerosis in apolipoprotein E-deficient mice.

17. SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells

18. Up-regulation of TLR7 could eliminate intracellular Mtb through autophagy

19. conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation

20. activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder

Cow (Bovine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.

2. TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll-Like Receptors.

3. The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.

4. Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.

Horse (Equine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. The messenger RNA sequences and exon/intron structures of Toll-like receptors 3, 7, and 8 were determined.

Pig (Porcine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. expression of TLR3, TLR7 and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains

2. Porcine TLR7 and TLR8 genes from pig lymph node tissue, were cloned and characterized.

Goat Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.

Guinea Pig Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.