anti-TLR7 (TLR7) Antikörper

Human Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. Lower copy number (=1) of TLR7 gene confers a risk factor for ankylosing spondylitis susceptibility in Chinese males but protective factor in Chinese females.

2. variations in TLR7 and TLR8 genes modulate the clearance and progression of HCV infection with different magnitudes between sexes

3. Enhanced TLR7 expression owing to biallelism contributes to the higher risk of developing SLE.

4. Btk acts in the TLR7/8 pathway and mediates Ser-536 phosphorylation of p65 RelA and subsequent nuclear entry in primary human macrophages.

5. the miRNA profile did not significantly differ between SLE and APS, but was driven by the presence or absence of an IFN signature. TLR7 stimulation induced a general downregulation of miRNAs, similar to the pattern observed in SLE and APS patients.

6. TLR7 upregulation has a role in liver cancer cell proliferation involving lipid rafts

7. Study demonstrates that Hepatitis C virus (HCV) genomic RNA harbours specific sequences that initiate an anti-HCV immune response through TLR7 and TLR8 in various antigen presenting cells.

8. TLR7, TLR9, and JAK2 genes are potential biomarkers for systemic sclerosis. High TLR7 expression positively correlated with the late form of disease. Decreased levels of TLR9 and JAK2 mRNA were found in the patient's cohort in comparison to non-SSc individuals.

9. The results indicate that TLR7 up-regulation is related to Respiratory syncytial virus infection and the induction of oxidative stress and that TLR7 expression was mediated by the anti-inflammatory effects of Nrf2/ARE pathway inhibitors or agonists.

10. Thus, TLR7 and TLR8 might modulate different immune responses in monocytes and macrophages.

11. Positive rates of iNOS in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4, TLR7, TLR8, NF-kappaB p65, and iNOS in cervical epithelial cells were higher in CC group than in other groups.

12. Data suggest a central role of XBP1 in TLR7-induced IFNalpha production and identify XBP1 as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.

13. These findings suggest that increased EV71 and CA16 replication meditated by autophagy in 16HBE cells might promote degradation of the endosome, leading to suppression of the TLR7-mediated IFN-I signaling pathway.

14. The present study investigated the effects of vitamin D3 on the expression of TLR3, TLR7, and TLR9 in Systemic lupus erythematosus patients.

15. Data suggest that IRAK4 activity regulates activation of IRF5, TAK1, and IKKB in monocytes; IRAK4 activation of TAK1-IKKB-IRF5 axis leads to induction of cytokines and interferons following TLR7/TLR8 stimulation. (IRAK4 = interleukin-1 receptor-associated kinase 4; IRF5 = interferon regulatory factor-5; TAK1 = MAPK kinase kinase 7; IKKB = I-kappa B kinase; TLR = toll-like receptor)

16. findings indicate that hepatitis C virus induces CD4 T cell impairment via TLR7 which may contribute to failure of virus eradication, casting doubts on the use of TLR7 agonists to boost innate immunity in chronic RNA virus infections.

17. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative oropharyngeal squamous cell carcinoma patients. In HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence.

18. Low TLR7 copy number is a risk factor for chronic hepatitis B virus infection but is not associated with later stages of disease progression

19. TLR7 and TLR8 genetic polymorphisms are associated with susceptibility to mycobacterium tuberculosis infection, and the link is shaped by less effective MTB phagocytosis and impaired TLR signaling.

20. Study evaluated innate immune profiles following TLR stimulation in HIV-1-infected mothers and newborns, found significantly compromised cytokine responses upon extracellular and intracellular TLR activation. Myeloid dendritic cell (DC) responsiveness appeared to be less impaired than plasmacytoid DCs, and might be enhanced through TLR7/TLR8 activation.

Mouse (Murine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC).

2. The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia.

3. TLR7 deletion reduces atherosclerosis in apolipoprotein E-deficient mice.

4. SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells

5. Up-regulation of TLR7 could eliminate intracellular Mtb through autophagy

6. conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation

7. activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder

8. Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 ligand poly I:C or TLR9 ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4(+) T cells, whereas activated CD8(+) T cells were dispensable

9. TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD.

10. Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation.

11. results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7.

12. these data demonstrate that TLR7/TLR9 ligands push the macrophage into a phagocytic long-lived cell, with a decreased capacity of antigen presentation and reminiscent of the M2 polarized state.

13. Virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.

14. the JAK-STAT pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 pathways.

15. TLR7 deficiency attenuates retinal damage in diabetic retinopathy model.

16. The data demonstrate that an atypical TLR7 signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7-driven type I IFN response plays an important role in determining the outcome of plague.

17. Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis

18. these data demonstrate that extracellular-miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) are potent innate immune activators and that the miRNAs most likely induce cytokine production and leukocyte migration through TLR7 signaling

19. study demonstrates that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells; further report that downregulation of STAT3 signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5

20. identification of a novel mechanism by which TLR and type I IFN synergize to promote monocyte/macrophage development from hematopoietic progenitors, a process critical in triggering rapid immune responses during infection

Cow (Bovine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. On day 104 of pregnancy, mRNA expression of TLRs 3 and 8, as well as that of TLRs 7 and 9, was high in the spleen of fetuses from Neospora caninum-infected heifers. Gene expression levels of endosomal TLRs were also detectable in the placenta and the maternal caruncle from infected heifers, being TLRs 3, 7 and 8 particularly upregulated, mostly in the caruncle.

2. TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll-Like Receptors.

3. The results from this study demonstrate that expression of at least TLR3, TLR7 and TLR8 is stimulated upon bovine alpha-herpesvirus infection of the brain.

4. Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.

Horse (Equine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. The messenger RNA sequences and exon/intron structures of Toll-like receptors 3, 7, and 8 were determined.

Pig (Porcine) Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. expression of TLR3, TLR7 and TLR9 in alveolar macrophages infected with different genotype 1 PRRSV strains

2. Porcine TLR7 and TLR8 genes from pig lymph node tissue, were cloned and characterized.

Goat Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.

Guinea Pig Toll-Like Receptor 7 (TLR7) Interaktionspartner

1. Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.