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Addition of TNFalpha to podocytes causes CD80 upregulation, actin reorganization and podocyte injury.
Urinary CD80 levels were significantly higher in the children with minimal change disease than in the controls and patients with other causes of nephrotic syndrome.
Results showed novel genetic associations with bone phenotypes and points to the CD80 gene as relevant in postmenopausal bone loss.
Increased expressions of TLR-3 (zeige TLR3 Proteine), TLR-4 (zeige TLR4 Proteine) and CD80 mRNA and the level of urinary CD80/creatinine could be useful markers to differentiate patients of steroid-sensitive nephrotic syndrome in relapse from those with steroid-resistant nephrotic syndrome.
Tregs were observed to regulate CD4 (zeige CD4 Proteine)(+), but not CD8 (zeige CD8A Proteine)(+), T cell infiltration into tumors through a CTLA-4 (zeige CTLA4 Proteine)/CD80 dependent mechanism. Disrupting CTLA-4 (zeige CTLA4 Proteine) interaction with CD80 was sufficient to induce CD4 (zeige CD4 Proteine) T cell infiltration into tumors.
Results show that CD80 down-regulation is associated to aberrant DNA methylation (zeige HELLS Proteine) in dysplasia of sporadic colonic carcinogenesis. This study indicates that the failure of immune surveillance mechanisms in non-inflammatory colon carcinogenesis may be linked to genomic methylation directly or indirectly affecting CD80 expression.
CTLA-4 (zeige CTLA4 Proteine)(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
The expression of B7-H6 (zeige NCR3LG1 Proteine) is up-regulated in U87-derived glioma stem like cells.
PD-1 (zeige PDCD1 Proteine) receptor has a role in interacting with programmed cell death ligands and B7-1
CD80-QPAR platform provides a useful predictive model for unknown RA extract's bioactivities using the chemical fingerprint inputs
CD28 (zeige CD28 Proteine) may play a role in LPS (zeige TLR4 Proteine) nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 in the kidney. High B7-1 expression was detected in podocytes treated with LPS (zeige TLR4 Proteine).
CD80 regulates Th17 differentiation in Coxsackie virus B3-induced acute myocarditis.
The study showed an association between CD80 and bone mineral density and the risk of osteoporosis.
this study shows that CD80 expressed by CD8 (zeige CD8A Proteine)(+) T cells contributes to PD-L1 (zeige CD274 Proteine)-induced apoptosis of activated CD8 (zeige CD8A Proteine)(+) T cells
TNFalpha (zeige TNF Proteine) is a prominent mediator of renal CD80 induction and resultant albuminuria.
findings do not support a role for B7-1 in podocyte biology
PD-L1 (zeige CD274 Proteine) interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 (zeige CD8A Proteine)+ T cells
Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD80.
Northern analysis revealed CD80 and CD86 (zeige CD86 Proteine) mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
B-lymphocyte activation antigen B7
, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
, CTLA-4 counter-receptor B7.1
, T-lymphocyte activation antigen CD80
, activation B7-1 antigen
, costimulatory factor CD80
, costimulatory molecule variant IgV-CD80
, CD80 antigen
, Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)
, B7 protein
, B7-1 protein
, T-cell co-stimulatory protein B7-1