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Addition of TNFalpha to podocytes causes CD80 upregulation, actin reorganization and podocyte injury.
Urinary CD80 levels were significantly higher in the children with minimal change disease than in the controls and patients with other causes of nephrotic syndrome.
Results showed novel genetic associations with bone phenotypes and points to the CD80 gene as relevant in postmenopausal bone loss.
Increased expressions of TLR-3, TLR-4 and CD80 mRNA and the level of urinary CD80/creatinine could be useful markers to differentiate patients of steroid-sensitive nephrotic syndrome in relapse from those with steroid-resistant nephrotic syndrome.
The rs1915087 (C>T), rs6804441 (A>G) and rs41271391 (G>T) of B7 antigens were suspected as the factors associated with reduced risk of recurrent spontaneous abortion.
Tregs were observed to regulate CD4(+), but not CD8(+), T cell infiltration into tumors through a CTLA-4/CD80 dependent mechanism. Disrupting CTLA-4 interaction with CD80 was sufficient to induce CD4 T cell infiltration into tumors.
Results show that CD80 down-regulation is associated to aberrant DNA methylation in dysplasia of sporadic colonic carcinogenesis. This study indicates that the failure of immune surveillance mechanisms in non-inflammatory colon carcinogenesis may be linked to genomic methylation directly or indirectly affecting CD80 expression.
Fabry disease is characterized by early occurrence of increased uCD80 excretion that appears to be a consequence of glycolipid accumulation.
CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
The expression of B7-H6 is up-regulated in U87-derived glioma stem like cells.
PD-1 receptor has a role in interacting with programmed cell death ligands and B7-1
CD80-QPAR platform provides a useful predictive model for unknown RA extract's bioactivities using the chemical fingerprint inputs
this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD80
B7-1 is not expressed by podocytes in LN. A renoprotective effect of B7-1 blockade in LN patients cannot be ruled out but, if confirmed, cannot be the result of an effect on podocyte B7-1
analysis of CTLA4-Ig in B7-1-positive diabetic and non-diabetic kidney disease [review]
Genetic interaction of CD80 and ALOX5AP was observed in systemic lupus erythematosus in Asian populations.
Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2.
B7-1 is not induced in podocytes from patients with minimal change disease or focal segmental glomerulosclerosis.
In the present study, we investigated the prognostic significance of the expression of three genes in the PD-L1 pathway, including PD-L1, B7.1 and PD-1, in three independent bladder cancer datasets in the Gene Expression Omnibus database.
CD28 may play a role in LPS nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 in the kidney. High B7-1 expression was detected in podocytes treated with LPS.
CD80 regulates Th17 differentiation in Coxsackie virus B3-induced acute myocarditis.
The study showed an association between CD80 and bone mineral density and the risk of osteoporosis.
this study shows that CD80 expressed by CD8(+) T cells contributes to PD-L1-induced apoptosis of activated CD8(+) T cells
TNFalpha is a prominent mediator of renal CD80 induction and resultant albuminuria.
findings do not support a role for B7-1 in podocyte biology
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells
Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD80.
The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH.
These results indicate that B7H1/CD80 interaction augments Tcon cell proliferation, IL-2 production, and expression of PD-1, which leads to increased apoptosis
CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation.
demonstrates that the simultaneous silencing of CD40 and CD80 genes has synergistic effects in preventing allograft rejection, and may therefore have therapeutic potential in clinical transplantation
cardiomyocytes can express CD80; this expression pattern can resist CTL-mediated lysis through CTLA-4 pathway
data show an important role of the adaptive immune system, in particular T cell CD80/86 costimulation molecules, in the physiological regulation of bone resorption and preservation of bone mass
CD80 and CD86 costimulatory molecules regulate OT-II CD4(+) T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice
The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice.
demonstrate that subcategorizing memory B cells on the basis of their expression of CD80 and PD-L2
the critical CD28/B7 interactions, required to generate Th2 cells, may directly occur between CD4 T cells engaged with the same B cell acting as an APC.
Northern analysis revealed CD80 and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
B-lymphocyte activation antigen B7
, CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
, CTLA-4 counter-receptor B7.1
, T-lymphocyte activation antigen CD80
, activation B7-1 antigen
, costimulatory factor CD80
, costimulatory molecule variant IgV-CD80
, CD80 antigen
, Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1)
, B7 protein
, B7-1 protein
, T-cell co-stimulatory protein B7-1