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Human CD4 Protein expressed in Human Cells - ABIN2002783
Ryu, Truneh, Sweet, Hendrickson: Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. in Structure (London, England : 1993) 1994
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Mouse (Murine) CD4 Protein expressed in Human Cells - ABIN2007381
Baldzizhar, Fedorchuk, Jha, Rathinam, Henegariu, Czyzyk: Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. in The Journal of biological chemistry 2013
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data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N).
results suggest that CD4 CD8 (zeige CD8A Proteine) double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT (zeige NT5C Proteine) cells
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
High-fat diet - induced type 2 diabetes decreases the number of ileum IL17 (zeige IL17A Proteine)/RORgammaT CD4 T cells.
Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression.
CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (zeige YES1 Proteine) p56lck (zeige LCK Proteine)
This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages.
5-kb cis (zeige CISH Proteine)-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis (zeige CISH Proteine)-element by DNA methylation (zeige HELLS Proteine)
Both type I CD8 (zeige CD8A Proteine)+ cytotoxic (Tc1 (zeige C8orf4 Proteine)) cells and interleukin (IL)-17 (zeige IL17A Proteine)-producing CD8 (zeige CD8A Proteine)+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 (zeige C8orf4 Proteine) cells are superior to Tc17 cells in mediating tumor regression.
Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function.
Our results indicate that CD4 expression and older age are adverse prognostic factors in wild-type NPM1 (zeige NPM1 Proteine), FLT3 (zeige FLT3 Proteine)-ITD-negative CN-AML (zeige RUNX1 Proteine).
We investigated the prevalence, magnitude and phenotype of CTAg (zeige CTAG1B Proteine)-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8 (zeige CD8A Proteine)(+) and CD4(+) T-cell responses against MAGE (zeige MAGEB10 Proteine)-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-gamma (zeige IFNG Proteine) ELISPOT. Spontaneous T-cell immunity against CTAg (zeige CTAG1B Proteine) proteins therefore develops in many patients with testicular cancer.
Depletion of the gamma2 or mu1A (AP1M1 (zeige AP1M1 Proteine)) subunits of AP-1 (zeige FOSB Proteine), but not of gamma1 (AP1G1 (zeige AP1G1 Proteine)), precludes Nef-mediated lysosomal degradation of CD4.
findings provide a mechanistic explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretroviral drug development
Mouse leukemia cell lines that could express hCD4 and CCR5 were thus established to facilitate normal entry of HIV-1 so that a human CD4/CCR5 transgenic mice cell model can be used to investigate the transmission and pathogenesis of HIV/AIDS and potential antiviral drugs against this disease.
The percentage of lamina propia CD4+LAP+ cells is increased in active ulcerative colitis, showing reduced suppressor activity due to their increased proportion of intracellular IL-17 (zeige IL17A Proteine) expression.
The study gives insights into the role of CD4 on cell membrane mechanical characteristics.
A decrease of CD4(+) CD25 (zeige IL2RA Proteine)(+) CD127 (zeige IL7R Proteine)(low) FoxP3 (zeige FOXP3 Proteine)(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients.
Redox shuffling of the allosteric disulfide results in previously undescribed conformational changes in CD4 that are likely important for its interaction with its protein partners.
Increased levels of activated and highly susceptible HIV-1 target cells, reduced CD4 and enhanced CXCR4 (zeige CXCR4 Proteine) cell surface expression, together with the high susceptibility to FAS (zeige FAS Proteine)-induced programmed cell death may contribute to the rapid CD4+ T cell depletion.
The frequency and expression of a CD4 variant in microminipigs are described.
These data help clarify the regulatory mechanism of DNA methylation (zeige HELLS Proteine) of the CD4 gene in non-immune cell response to virus replication.
These results suggest that CD4 plays a role in production traits as well as in immune function. The identified SNPs could be used as genetic markers for selection of dairy cows with improved fat percentage. We propose further studies of these SNPs in a larger population as well as further investigations of the function of this gene.
These results suggested that the SNPs in CD4 and STAT5b (zeige STAT5B Proteine) may be potential genetic markers for SCS (zeige TWIST1 Proteine) and milk/protein (zeige CSN2 Proteine) yields selecting and warrant further functional research.
The DNA methylation (zeige HELLS Proteine) level of the CD4 gene was strongly influenced by mastitis in Chinese Holstein cattle.
These findings revealed that despite the existence of a distinct bovine CD4(+)CD25 (zeige IL2RA Proteine)(high) T cell population, which showed Foxp3 (zeige FOXP3 Proteine) transcription/expression, natural regulatory activity did not reside in this cell population
The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.
study found noticeable variation in the first variable region V1 of CD4 and in intron six among the subspecies of chimpanzees.
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
, T-cell surface glycoprotein CD4
, T-cell differentiation antigen L3T4
, T-cell surface antigen T4/Leu-3
, T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
, CD4 antigen (p55)
, CD4 receptor
, W3/25 antigen
, lymphocyte antigen CD4
, cell surface glycoprotein CD4