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Human beta-2 Microglobulin Protein expressed in Insect Cells - ABIN1305114
Shields, Moffat, Ribaudo: Functional comparison of bovine, murine, and human beta2-microglobulin: interactions with murine MHC I molecules. in Molecular immunology 1999
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Human beta-2 Microglobulin Protein expressed in Human - ABIN935619
Neethling, Ramakrishna, Keler, Buchli, Woodburn, Weidanz: Assessing vaccine potency using TCRmimic antibodies. in Vaccine 2008
Molecular dynamic simulations reveal that D59P mutation in the DE loop region of B2M disrupts the native sandwich folded structure and highlight a decrease in the average number of hydrogen bonds in the loop regions on D59P mutation that enhances conformational flexibility, which lead to higher aggregation propensity.
We focused on the genetic and functional analysis of beta2-microglobulin (B2M), a component of the HLA class-I (zeige MICA Proteine) complex. We identified alterations in genes involved in various functions, such as B2M involved in immunosurveillance
Both cystatin C (zeige CST3 Proteine) and beta 2 macroglobulin are elevated in type 2 diabetics with diabetic nephropathy.
Serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of diseased coronary vessels.
Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M.
High B2M levels were associated with an increased risk of ischemic stroke in this study of middle-aged women
Letter: serum levels of anti-carbonic anhydrase autoantibodies and beta macroglobulin correlate with ClinESSDAI score in patients with Sjogren's syndrome.
Beta2M mRNA expression in cells of the urinary sediment is higher in T1D patients with diabetic kidney disease and in patients with focal segmental glomerulosclerosis in comparison to healthy subjects, maybe reflecting a tubulointerstitial injury promoted by albumin (zeige ALB Proteine).
Serum levels of beta trace protein and beta 2 microglobulin can be used to predict residual kidney function in hemodialysis patients.
The chaperone crystallin, which is a mild modulator of the lag (zeige STMN1 Proteine) phase of the variant fibrillogenesis, potently inhibits fibril elongation of the wild-type even once it is absorbed on D76N beta2-microglobulin fibrils.
The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.
Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients.
systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis
Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.
We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens.
The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN (zeige RBFOX3 Proteine) and gFAP (zeige GFAP Proteine) expression in different sections of the brain in mice.
MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex
Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis
Data show that tapasin (zeige TAPBP Proteine) expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.
B2M contains alpha-helix, beta-sheet, turn, and random coil.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
beta chain of MHC class I molecules
, beta-2-microglobulin C-terminal fragment (55 AA)
, beta 2-microglobulin
, beta-2 microglobulin
, beta 2 microglobulin
, beta-2-microglobulin-like protein
, beta2 microglobulin
, beta 2-m
, beta 2 microglobulin (54 AA)