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Human beta-2 Microglobulin Protein expressed in Insect Cells - ABIN1305114
Shields, Moffat, Ribaudo: Functional comparison of bovine, murine, and human beta2-microglobulin: interactions with murine MHC I molecules. in Molecular immunology 1999
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Human beta-2 Microglobulin Protein expressed in Escherichia coli (E. coli) - ABIN2128134
Neethling, Ramakrishna, Keler, Buchli, Woodburn, Weidanz: Assessing vaccine potency using TCRmimic antibodies. in Vaccine 2008
An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.
Study observed differences in B2M mutation status in mismatch repair-deficient CRC by tumor subtypes, site, stage, grade, immune infiltrate and for overall survival that warrant further investigation in larger studies before B2M mutation status can be considered to have clinical utility.
Data show that plasma beta2-microglobulin (beta2m) levels are specifically increased in Alzheimer's disease (AD), indicating that beta2m could play a role in AD.
Binding stability to beta2-microglobulin may confer to HLA-C the ability to preferentially act either as a conventional immune-competent molecule or as an accessory molecule involved in HIV-1 infectivity via viral envelope glycoprotein binding.
Molecular dynamic simulations reveal that D59P mutation in the DE loop region of B2M disrupts the native sandwich folded structure and highlight a decrease in the average number of hydrogen bonds in the loop regions on D59P mutation that enhances conformational flexibility, which lead to higher aggregation propensity.
Study characterized the salt-induced oligomers of the acid-unfolded state of beta2m using an array of biophysical tools including steady-state and time-resolved fluorescence, circular dichroism, dynamic light scattering, and atomic force microscopy imaging. Results revealed the distinct pathways by which beta2m assembles into oligomers and fibrils.
We focused on the genetic and functional analysis of beta2-microglobulin (B2M), a component of the HLA class-I complex. We identified alterations in genes involved in various functions, such as B2M involved in immunosurveillance
Pretransplant beta2-Microglobulin Is Associated with the Risk of Acute Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplant.(
we found that beta2M but no other serum markers had independent prognostic significance in the UK CLL4 trial
Both cystatin C and beta 2 macroglobulin are elevated in type 2 diabetics with diabetic nephropathy.
Serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of diseased coronary vessels.
Data suggest that T-cell receptor (TCR) alpha-constant domain (C- and F-strands) directly interacts with unbound MHC light chain, beta2-microglobulin (beta2M); these interactions do not appear to be involved in T-cell cytotoxicity, suggesting an alternate role for beta2M binding to TCR; TCR beta-chain does not appear to interact directly with beta2M.
These data suggest beta2M might participate in the development of lung emphysema through induction of lung epithelial cell senescence and inhibition.
Heparin-induced amyloid fibrillation of beta2 -microglobulin explained by solubility and a supersaturation-dependent conformational phase diagram
results suggest that doxycycline and rifamycin are general inhibitors of Cu(II)-induced beta2m amyloid formation.
High B2M levels were associated with an increased risk of ischemic stroke in this study of middle-aged women
Letter: serum levels of anti-carbonic anhydrase autoantibodies and beta macroglobulin correlate with ClinESSDAI score in patients with Sjogren's syndrome.
Macromolecular crowding favors the fibrillization of beta2-microglobulin by accelerating the nucleation step and inhibiting fibril disassembly.
Beta2M mRNA expression in cells of the urinary sediment is higher in T1D patients with diabetic kidney disease and in patients with focal segmental glomerulosclerosis in comparison to healthy subjects, maybe reflecting a tubulointerstitial injury promoted by albumin.
Serum levels of beta trace protein and beta 2 microglobulin can be used to predict residual kidney function in hemodialysis patients.
When no programmed delay interval was imposed, the beta2m-deficient mice acquired the task as fast as controls, suggesting that discrimination of left and right positions is not impaired by the total loss of hippocampal asymmetry. beta2m-deficient mice made fewer correct responses than control mice when variable delay was imposed, suggesting that the asymmetry of hippocampal circuitry plays an important role in working...
The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.
Use of shRNA against beta-2-microglobulin offers a simple and effective approach to minimize immunogenicity of the main cellular components of cardiac tissue constructs in non-syngeneic recipients.
systemic B2M accumulation in aging blood promotes age-related cognitive dysfunction and impairs neurogenesis
Because all forms of H-2K(b) are internalized but little beta2m-receptive heavy chain is present at the cell surface, it is likely that beta2m dissociation and recognition of the heavy chain for lysosomal degradation take place in an endocytic compartment.
We report a novel dichotomous role of beta2m and CD1d, whereby these molecules differently regulate autoimmunity against phospholipid versus non-phospholipid autoantigens.
The goal of the present work was to study peculiarities in functioning of proteasomes and associated signaling pathways along with evaluation of NeuN and gFAP expression in different sections of the brain in mice.
MHC I and b2m genes are both expressed in in human as well as mice during the developmental stages of cerebellar cortex
Knocking out beta 2 microglobulin abolishes NMDAR-dependent LTD in area CA1 of adult mouse hippocampus and is accompanied by memory deficits. MHC class I expression could be an unexpected cause of disrupted synaptic plasticity and cognitive deficits.
This study demonistrated that Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis
Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.
This gene is known to be important for immune responses and may potentially regulate alcohol consumption.
Data show that NK subsets bearing Ly49s, which bind "self-MHC" were found to be the dominant subset responsible for beta2m(-/-) BMC rejection.
Skin graft rejection induced by B2m-derived minor transplantation antigens involves Th2-dependent eosinophilic rejection, IFN-gamma dependent mechanisms, and Fas-Fas ligand interactions.
beta-2 microglobulin knockout-anti-asialoGM1 mice exhibit improved hemodynamics and cardiac contractile function after cecal ligation and puncture that may account, in part, for survival benefit
Rag1 deficiency in Hfe knock-out mice leads to heightened iron overload, mainly in the liver, whereas the heart and pancreas are relatively spared compared with beta2mRag1(-/-) mice.
Beta 2 microglobulin deficient mice react normally to endotoxin and their hepatocytes react normally to IL-6.
Results show that a seven-residue segment of human beta2-microglobulin (beta2M), not found in mouse beta2M, is sufficient to convert beta2M to the amyloid state, and that specific residue interactions are crucial to the conversion.
Knockout mice represent an instructive model of spontaneous iron overload resembling genetic hemochromatosis.
Experimental autoimmune encephalomyelitis in beta 2-microglobulin(beta2m)-deficient mice is significantly more severe, with a 10-fold increased mortality in beta2m-null mice as compared to wild-type C57BL/6 mice.
Crystallization and preliminary X-ray diffraction analysis of the two distinct types of zebrafish beta2-microglobulin has been reported.
B2M contains alpha-helix, beta-sheet, turn, and random coil.
Despite the absence of beta2-microglobulin, histocompatibility class I A spliced- variant proteins reach the cell surface during transfection as glycoproteins that can form disulfide-bonded homodimers.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
beta chain of MHC class I molecules
, beta-2-microglobulin C-terminal fragment (55 AA)
, beta 2-microglobulin
, beta-2 microglobulin
, beta 2 microglobulin
, beta-2-microglobulin-like protein
, beta2 microglobulin
, beta 2-m
, beta 2 microglobulin (54 AA)