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anti-Human Aurora Kinase B Antikörper:
anti-Mouse (Murine) Aurora Kinase B Antikörper:
anti-Rat (Rattus) Aurora Kinase B Antikörper:
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Human Polyclonal Aurora Kinase B Primary Antibody für ICC, IF - ABIN151760
Adams, Eckley, Vagnarelli, Wheatley, Gerloff, Mackay, Svingen, Kaufmann, Earnshaw: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. in Chromosoma 2001
Show all 11 Pubmed References
Human Polyclonal Aurora Kinase B Primary Antibody für ICC, IF - ABIN152999
Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006
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Human Monoclonal Aurora Kinase B Primary Antibody für ELISA, WB - ABIN965626
Song, So, Cheng, Tang, Croft: Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. in Immunity 2005
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Human Monoclonal Aurora Kinase B Primary Antibody für ELISA, WB - ABIN1724660
Kapoor, Lavoie, Frappier: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. in Molecular and cellular biology 2005
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Human Polyclonal Aurora Kinase B Primary Antibody für EIA, WB - ABIN117978
Honda, Asato, Tanaka, Endo, Nishimura, Ito: Vidian nerve schwannoma with middle cranial fossa extension resected via a maxillary swing approach. in Head & neck 2008
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Chimpanzee Polyclonal Aurora Kinase B Primary Antibody für ELISA, WB - ABIN2477557
Klever, Grond-Ginsbach, Hager, Schroeder-Kurth: Chorionic villus metaphase chromosomes and interphase nuclei analysed by chromosomal in situ suppression (CISS) hybridization. in Prenatal diagnosis 1992
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Human Polyclonal Aurora Kinase B Primary Antibody für WB - ABIN2441645
Bailey, Fields, Cheng, Lee, Wagenaar, Lagrois, Schmidt, Xia, Ma: WD repeat-containing protein 5 (WDR5) localizes to the midbody and regulates abscission. in The Journal of biological chemistry 2015
Human Polyclonal Aurora Kinase B Primary Antibody für ELISA, WB - ABIN129612
Mackay, Makise, Ullman: Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. in The Journal of cell biology 2010
We also suggested Aurora-B as a promising therapeutic target in non-small cell lung cancer treatment.
The epigenetic targets AURKB, AURKC (zeige AURKC Antikörper) and DNMT3B (zeige DNMT3B Antikörper), and the global DNA methylation (zeige HELLS Antikörper) profile are regulated during HIV-1 replication in CD4 (zeige CD4 Antikörper)+ T cells, and this regulation can be influenced by the activation state of the cell at the time of infection.
findings suggest that USP35 regulates the stability and function of Aurora B by blocking APC (zeige APC Antikörper)(CDH1 (zeige CDH1 Antikörper))-induced proteasomal degradation, thereby controlling mitotic progression
PKCvarepsilon directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S227. This phosphorylation invokes a switch in Aurora B specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin (zeige CDCA8 Antikörper).
The results propose a model in which Aurora B-mediated H2AX (zeige H2AFX Antikörper)-phosphorylated serine 121 probably provide a platform for Aurora B autoactivation circuitry at centromeres and thus play a pivotal role in proper chromosome segregation.
The data suggest that AKA (zeige NEUROG1 Antikörper) is the vertebrate ancestral gene, and that AKB and AKC resulted from gene duplication in placental mammals.
Study reveals the mechanism controlling abscission through integration of Aurora B kinase and B56-bound PP2A (zeige PPP2R4 Antikörper) phosphatase activities on the kinesin motor protein (zeige KIF16B Antikörper) MKlp2 (zeige KIF20A Antikörper). MKlp2 (zeige KIF20A Antikörper) is an essential protein for promoting abscission, which may regulate tethering and stabilizing of the PM to the microtubule cytoskeleton at the intercellular bridge through its previously uncharacterized lipid association motif.
we identified deguelin as an effective Aurora B inhibitor, which deserves further studies in other animal models and esophageal squamous cell carcinoma treatment
Our data show that S49076 exerts its cytotoxic activity at low doses on MET-dependent cells through MET inhibition, whereas it inhibits growth of MET-independent cells at higher but clinically relevant doses by targeting Aurora B
Results show the overexpression Aurkb decreased glycolytic activities and suggest that AURKB is involved in asthenozoospermia.
The results propose a model in which Aurora B (zeige AURKC Antikörper)-mediated H2AX (zeige H2AFX Antikörper)-phosphorylated serine 121 probably provide a platform for Aurora B (zeige AURKC Antikörper) autoactivation circuitry at centromeres and thus play a pivotal role in proper chromosome segregation.
Data show that phosphorylated Ku70 (zeige XRCC6 Antikörper) S155 interacts with the Aurora B kinase and leads to inhibition of its activity.
Loss of AURKB function affects TERF1 (zeige TERF1 Antikörper) telomere binding and results in aberrant telomere structure.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB or AURKC (zeige AURKC Antikörper) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (zeige AURKA Antikörper) expression is crucial for spindle formation in meiosis
Aurkb phosphorylates Oct4 (zeige POU5F1 Antikörper)(S229) during G2/M phase, leading to the dissociation of Oct4 (zeige POU5F1 Antikörper) from chromatin, whereas PP1 (zeige PPP1CC Antikörper) binds Oct4 (zeige POU5F1 Antikörper) and dephosphorylates Oct4 (zeige POU5F1 Antikörper)(S229) during M/G1 transition, which resets Oct4 (zeige POU5F1 Antikörper)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (zeige AURKC Antikörper) also results in a reduced DNA damage response and decreased levels of the p53 (zeige TP53 Antikörper) target p21(Cip1 (zeige CDKN1A Antikörper)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (zeige AURKC Antikörper) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (zeige AURKC Antikörper) at the inner centromere region in cells lacking Pds5B (zeige PDS5B Antikörper) impairs its error correction function, promoting chromosome mis (zeige AMH Antikörper)-segregation and aneuploidy
Aurora B (zeige AURKC Antikörper) and Ring1B (zeige RNF2 Antikörper) co-occupy active promoters in resting lymphocytes.
Aurora A (zeige AURKA Antikörper) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B and Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (zeige CDC37 Antikörper)/Hsp90 (zeige HSP90 Antikörper) complex for its stability.
INCENP (zeige INCENP Antikörper) binds to the cohesion protector protein (zeige PRDX2 Antikörper) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Alterations in PGRMC1 (zeige PGRMC1 Antikörper) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
Data suggest a model in which microtubules act as scaffolds for the enzymatic activity of Aurora-B.
Data report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP (zeige INCENP Antikörper)) activator and with the small molecule inhibitor Hesperadin.
ICIS (zeige MTUS1 Antikörper) and Aurora B coregulate the microtubule depolymerase Kif2a (zeige KIF2A Antikörper).
the Aurora B chromosome passenger protein complex, including INCENP and survivin, is regulated during oocyte maturation in Xenopus laevis
This study reveals a new role for Aurora B, which is to prevent excess MCAK (zeige KIF2C Antikörper) binding to chromatin to facilitate chromatin-nucleated spindle assembly.
MCAK (zeige KIF2C Antikörper) regulation of cytoplasmic and spindle-associated (zeige HAUS1 Antikörper) microtubules can be differentiated by Aurora B-dependent phosphorylation
results suggest an essential combined function of AurA (zeige AURKA Antikörper) and AurB in chromosome segregation and anaphase MT dynamics
Aurora B pathway is suppressed in the cytoplasm of Xenopus egg extract by phosphatases, but that it becomes activated by chromatin via a Ran-independent mechanism.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, aurora/IPL1-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase 5
, serine/threonine-protein kinase aurora-B
, aurora B
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, aurora B kinase
, dAurora B
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, aurora kinase B
, serine/threonine-protein kinase 12-like
, Aurora/IPL1-related kinase 2-B
, Serine/threonine-protein kinase 12-B
, Serine/threonine-protein kinase aurora-B-B
, aurora kinase B-B
, aurora/IPL1-related kinase 2-B
, serine/threonine-protein kinase 12-B
, serine/threonine-protein kinase aurora-B-B