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Ca(2+)-binding pocket of synaptotagmin 5 C2A domain
crystals of synaptotagmin 5 belonged to the hexagonal space group P6(5), with unit-cell parameters a = b = 93.97, c = 28.05 A.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
results suggest a novel putative functional role for the GST-synaptotagmin V complex in human breast cancers. As this association of GST M1-synaptotagmin was not seen in adjacent non-cancerous tissues, this can be used as a marker for breast cancers.
SYT7 and SYTL5 were positive regulators of chemotaxis
Synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles.
focal exocytosis of endocytic organelles is a key event in phagocytosis and suggest that Syt V regulates this process.
Anatomical distribution and functional properties of this synaptotagmin protein are revealed by conditional knock-out mice engineered to express a GFP tag introduced at the start of the first coding exon of this gene locus.
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995
, synaptotagmin IX
, synaptotagmin V