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Data show that both sall1 and sall4 act to repress pou5f3 (oct4)family gene expression in the neural plate, thereby allowing vertebrate neural development to proceed.
These results suggest that Sall4, activated by posteriorizing signals, represses the pou5f3 genes to provide a permissive environment.
SAL family member (XlSALL4) is expressed at the right place and time to play a role regulating both digit identity along the anterior/posterior axis and epimorphic limb regeneration
Sall4 expression expression in chemosensory cells implicates this transcription factor in the development and renewal of taste epithelia in zebrafish.
Sall gene family redundancy and tbx5 (zeige TBX5 Proteine) offer explanations for the similarity of individuals with Okihiro syndrome and Holt-Oram syndrome limb defects
Findings indicate that SALL4 critically contributes to MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine)-induced leukemia, unraveling the underlying transcriptional and epigenetic mechanisms in this disease.
SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 (zeige FOXL1 Proteine) and Dusp4 (zeige DUSP9 Proteine).
Study propose a model whereby enhancer binding by Sall4 and other pluripotency-associated transcription factors is responsible for maintaining the balance between transcriptional programmes in pluripotent cells.
SALL4 has a negative impact in DNA damage repair, and support the model of dual functional properties of SALL4 in leukemogenesis through inhibiting DNA damage repair and promoting cell survival.
these data reveal the full profile of PLZF (zeige ZBTB16 Proteine) and SALL4 regulatory targets in undifferentiated spermatogonia.
study explores a pivotal role of Sall4 in regulating epigenetic maturation of mouse oocytes.
JARID2 (zeige JARID2 Proteine) physically interacts with ESRRB, SALL4A, and PRDM14 (zeige PRDM14 Proteine)
As SALL4A is known to impair ZBTB16 (zeige ZBTB16 Proteine)-mediated Kit repression , our study provides novel insights into the molecular mechanism by which ATRA could control KIT expression, and thereby the differentiation of Aal into A1 spermatogonia in vivo.
In differentiated ESCs (zeige NR2E3 Proteine), Sall4 bound to these somatic cell program gene loci, which are reportedly occupied by Prdm1 (zeige PRDM1 Proteine) in embryonic carcinoma cells.
This study identified a critical role of the Sall4-Gli3 (zeige GLI3 Proteine) system at the early steps of limb development for proper development of the appendicular skeletal elements.
TNFSF13 (zeige TNFSF13 Proteine), SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population
Study showed significantly high expression of SALL4 mRNA in glioma specimens as compared to non-tumor samples using RT-PCR. Blocking SALL4 using SALL4-siRNA decreased proliferation of U87 and U251 cells, which was reversed by the addition of PTEN inhibitor phen (bpv). Furthermore, marked increase in PTEN mRNA and protein levels was seen in cells treated with siRNA-SALL4.
SALL4 is a promising prognostic biomarker for cancer, and is appropriate for the assessment of cancer prognosis in the Chinese people.
Our experimental data indicated that over expression of SALL4 was found in CRC (zeige CALR Proteine) and low expression of SALL4 was connected with high survival rate after surgery. Thus our study suggested that SALL4 could serve as a potential diagnostic and prognostic marker of CRC (zeige CALR Proteine).
SALL4 is a target gene of miR (zeige MLXIP Proteine)-181b in glioma.SALL4 is upregulated in glioma.
SALL4 is a target gene of mir (zeige MLXIP Proteine)-98 in non-small cell lung cancer cells.
miR (zeige MLXIP Proteine)-98 plays a suppressive role in the proliferation, migration, invasion and EMT (zeige ITK Proteine) of HCC (zeige FAM126A Proteine) cells, partly at least, via directly inhibition of SALL4.
SALL4 immunopositivity is not a prognostic factor in Combined hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) and cholangiocarcinoma (CC) (cHCC-CC); however, it is associated with alpha-fetoprotein (zeige AFP Proteine), glypican 3 (zeige GPC3 Proteine) and EpCAM (zeige EPCAM Proteine) immunopositivity, indicating the mechanism of carcinogenesis.
these data suggest that Bmi-1 (zeige BMI1 Proteine) could serve as a novel prognostic biomarker in pediatric primary acute lymphoblastic leukemia (ALL)and may be partially regulated by Sall4a. Our study also showed that Bmi-1 (zeige BMI1 Proteine) could serve as a new therapeutic target for the treatment of pediatric ALL.
SALL4 overexpression is associated with neoplasms.
The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS).
sal-like 4 (Drosophila)
, sal-like protein 4-like
, sal-like 4
, zinc finger transcription factor SALL4 a
, sal-like protein 4
, zinc finger protein SALL4
, zinc finger protein 797