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STAT3 (zeige STAT3 Proteine) bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells.
MRTF-A-miR (zeige MLXIP Proteine)-206-WDR1 form feedback loop to regulate breast cancer cell migration.
homozygous missense L153F/L293F mutation in the actin regulatory gene WDR1 causes a new autoinflammatory disease in humans, with periodic fevers, immunodeficiency, and intermittent thrombocytopenia (PFIT).
These data suggest that WDR1 plays an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics, and downregulation of WDR1 may contribute to the platelet-mediated pathogenesis of cardiovascular disease.
Mutations in WDR1 affect neutrophil morphology, motility, and function, causing a novel primary immunodeficiency
Identify positive correlations between WDR1 and CLNK (zeige CLNK Proteine) gene polymorphisms in Chinese-Tibetan gout populations.
Demonstrate a previously unanticipated role of Aip1 (zeige BIRC3 Proteine) in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis.
When maternal environmental tobacco smoke was considered, fifteen of 135 single nucleotide polymorphism (SNPs) mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance.
Data suggest that anti-WD repeat domain 1 (WDR1) antibody could be applied for serological screening of papillary thyroid carcinoma (PTC (zeige F9 Proteine)) and undifferentiated thyroid carcinoma (UTC), and could be an efficient and inexpensive biomarker.
WD repeat-containing protein 1 was confirmed as being significantly overexpressed in interstitial fluid from ovarian carcinomas compared to healthy ovarian tissue.
WDR1 interacts with Lim domain kinase 1 (LIMK1 (zeige LIMK1 Proteine)), a well known phosphorylation kinase of Cofilin (zeige CFL1 Proteine).
Wdr1 and cofilin (zeige CFL1 Proteine)/destrin (zeige DSTN Proteine)-mediated actomyosin remodelling are essential for generating or maintaining cortical tension within the developing epidermal sheet and driving the cell shape and planar orientation changes.
Wdr1-regulated actin dynamics play essential roles in heart function in mice. F-actin accumulations caused by Wdr1 deletion result in disruption of sarcomeric structure.
The QKI (zeige QKI Proteine) RNA-binding proteins regulate oligodendrocyte differentiation by modulating the expression of AIP-1.
studies establish an essential requirement for Wdr1 in megakaryocytes and neutrophils
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.
, WD repeat-containing protein 1
, actin-interacting protein 1
, WD40 repeat protein 1
, WD repeat protein 1