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anti-Human HOXA1 Antikörper:
anti-Mouse (Murine) HOXA1 Antikörper:
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Human Polyclonal HOXA1 Primary Antibody für IHC, IHC (p) - ABIN4319685
Lambert, Vandeputte, Desmet, Hallet, Remacle, Rezsohazy: Pentapeptide insertion mutagenesis of the Hoxa1 protein: mapping of transcription activation and DNA-binding regulatory domains. in Journal of cellular biochemistry 2010
Show all 3 Pubmed References
Human Polyclonal HOXA1 Primary Antibody für IF, WB - ABIN516595
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
Human Polyclonal HOXA1 Primary Antibody für ELISA, WB - ABIN4319684
Chakrabarti, Dudbridge, Kent, Wheelwright, Hill-Cawthorne, Allison, Banerjee-Basu, Baron-Cohen: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. in Autism research : official journal of the International Society for Autism Research 2009
Study identified HOXA1 as a direct target of miR (zeige MLXIP Antikörper)-30e. Its expression is down-regulated by miR (zeige MLXIP Antikörper)-30e played leading to suppressed lung cancer cell growth.
HOXA1-mediated activation of NF-kappaB (zeige NFKB1 Antikörper) is non-transcriptional and the RBCK1 (zeige RBCK1 Antikörper) and TRAF2 (zeige TRAF2 Antikörper) influences on NF-kappaB (zeige NFKB1 Antikörper) are epistatic to HOXA1
Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia (zeige BCL11A Antikörper).
Data indicated that HOXA1 and CCND1 (zeige CCND1 Antikörper) mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells.
In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness.
our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis
Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 (zeige DNMT1 Antikörper) & DNMT3b (zeige DNMT3B Antikörper) expression.
YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes.
Analysis indicates that the genes BIRC5 (zeige BIRC5 Antikörper), HOXA1 and RARB (zeige RARB Antikörper) are critical targets that play an important regulatory role in cervical cancer pathogenesis.
When Hoxa1, Hoxb1 (zeige HOXB1 Antikörper) and Hoxd1 (zeige HOXD1 Antikörper) are knocked down in combination, the hindbrain patterning phenotype is more severe than in the single or double knockdowns
Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.
Authors found evidence for a high degree of evolutionary conservation of many binding regions and downstream targets of Hoxa1 between mouse and zebrafish.
Data indicate that homeobox A1 (HOXA1) was a direct microRNA miR (zeige MLXIP Antikörper)-30b target in esophageal cancer (EC) cells.
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5 (zeige HOXA5 Antikörper), HoxC4 (zeige HOXC4 Antikörper) &HoxC8 (zeige HOXC8 Antikörper) markedly enhanced. Irrespective of presence or absence of T3, insulin (zeige INS Antikörper) down regulates HoxA10 (zeige HOXA10 Antikörper). T3 results in over expression of HoxA5 (zeige HOXA5 Antikörper), HoxC4 (zeige HOXC4 Antikörper) and HoxC8 (zeige HOXC8 Antikörper) genes, whereas insulin (zeige INS Antikörper) up regulates expression of only HoxC8 (zeige HOXC8 Antikörper)
These data suggest that Hoxb1 (zeige HOXB1 Antikörper) and Hoxa1 are more phenotypically divergent than previously reported and support that sub- and/or neofunctionalization has occurred in these paralogous genes leading to a divergence of gene function and incomplete redundancy
YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages.
Many Hoxa1 interactors are proteins involved in cell-signaling transduction, cell adhesion and vesicular trafficking.
Hoxa1 null mice show defects such as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot mimic the defects in HoxA1 syndrome patients.
Hoxa1 acts in a genetic cascade upstream of genes controlling specific aspects of embryonic development.
Hoxa1 lineage tracing uncovered new domains of Hoxa1 expression in rhombomere 3, the otic epithelium, and cardiac precursors, suggesting a more direct role for Hoxa1 in development of these tissues than previously believed.
Data suggest that, in developing gastrula, Znfl1 controls developmental gene expression of Hoxb1b in embryonic posterior neuroectoderm by acting upstream of Pou5f3 and Sall4 (zeige SALL4 Antikörper); these proteins appear to be involved in neurogenesis. (Znfl1 = zinc finger-like gene 1; Hoxb1b = homeobox B1b protein; Pou5f3 = POU domain class 5 transcription factor 3 (zeige TCF3 Antikörper); Sall4 (zeige SALL4 Antikörper) = spalt (zeige SALL1 Antikörper)-like transcription factor 4 (zeige TCF4 Antikörper))
Data indicate that hox genes hoxb1a and hoxb1b have separate functions in hindbrain development.
Hoxb1b regulates mitotic spindle rotation during the oriented neural keel symmetric mitoses that are required for normal neural tube lumen formation in the zebrafish.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
HOX A1 homeodomain protein
, Hox 1.6-like protein
, homeo box A1
, homeobox 1F
, homeobox protein Hox-1F
, homeobox protein Hox-A1
, lab-like protein
, homeobox A1
, homeobox A1, isoform 1
, early retinoic acid 1
, homeobox protein Hox-1.6
, homeoboxless protein ERA-1-399
, homeotic protein ERA-1-993
, homeobox protein
, homeobox b1b
, homeobox gene A-1
, homeobox protein Hox-B1b