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HOTAIR promoted glycolysis by upregulating glucose transporter isoform 1 (GLUT1) and activating mammalian target of rapamycin (mTOR (zeige FRAP1 Proteine)) signaling.
In preeclampsia, placental GLUT1 expression and function are down-regulated at the apical plasma membrane of the syncytiotrophoblast.
High glut1 expression is associated with Pancreatic Cancer.
Study confirms the high expression of Glut-1 not only in endometrioid carcinomas but also in other carcinomas of endometrium including clear cell and serous types. Glut-1 expression can be used as a surrogate marker in differential diagnosis between hyperplasia with and without atypia.
This systematic review and meta-analysis indicated that the GLUT1 may serve as an ideal prognostic biomarker in various cancers.
This study did not detect any pathogenic mutations in SLC2A1 in the patient with focal epilepsy.
Taken together, our study provides a new perspective of miR (zeige MLXIP Proteine)-148b in gastric cancer (GC) development through inhibiting glycolysis in GC cells , directly targeting glucose transporter SLC2A1.
Data suggest that plasma glycation with erythrocyte membrane modification is associated with oxidative stress, GLUT1 expression, and erythrocyte fragility in patients with type 2 diabetes; such glycation may further contribute to progression of diabetic vascular complications.
Antibody therapy targeted at AFP-producing tumor cells showed an inhibitory effect on the PI3K/AKT pathway via the liberation, restoration and functional stabilization of PTEN. PTEN simultaneously induced both P53 activation and intracellular translocation of GLUT1, since these are closely associated with PTEN.
FOXM1 (zeige FOXM1 Proteine) bound directly to the GLUT1 and HK2 (zeige HK2 Proteine) promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1 (zeige FOXM1 Proteine).
Immunoreactivity of vGluT1 in continuous theta-burst stimulation (iTBS; cTBS (zeige CTBS Proteine)) repeated session (RS) decreased, while GLT-1 (zeige SLC1A2 Proteine) increased in cTBS (zeige CTBS Proteine) SS and cTBS (zeige CTBS Proteine) RS, compared to control
Expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE (zeige RPE Proteine) secretory function of PEDF (zeige SERPINF1 Proteine).
GLUT1 may play an important role in Prostate Cancer progression via mediating glycolysis and proliferation. There is potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in Prostate Cancer.
ARAP2 knockdown did not affect fatty acid uptake but reduced basal glucose uptake, total levels of the glucose transporter GLUT1, and GLUT1 levels in the plasma membrane and the lipid micro-domain fraction.
TBC1D5 (zeige TBC1D5 Proteine) shuttling to autophagosomes during metabolic stress facilitates retromer-dependent GLUT1 trafficking.
inhibition of GLUT1 activity and/or expression is shown to impair TGF-beta (zeige TGFB1 Proteine)-driven fibrogenic processes, including cell proliferation and production of profibrotic mediators
B cell leukemia-induced inhibition of T cell Akt (zeige AKT1 Proteine)/mTORC1 signaling and glucose metabolism drives T cell dysfunction; metabolic defects included reduced Akt (zeige AKT1 Proteine)/mammalian target of rapamycin (zeige FRAP1 Proteine) complex 1 (mTORC1) signaling, decreased expression of the glucose transporter Glut1 and hexokinase 2 (zeige HK2 Proteine), and reduced glucose uptake
This study demonstrates a strict requirement for GLUT1 in the early stages of mammary tumorigenesis in vitro and in vivo.
GLUT1-dependent glycolysis regulates fibrogenesis in aged lung.
Data (including data from studies using transgenic mice) suggest that Glut1 (glucose transporter type 1) is a critical downstream target of Hif1a (hypoxia-inducible factor 1 (zeige HIF1A Proteine), alpha subunit (zeige POLG Proteine)) mediating hyperglycemia-induced extracellular matrix accumulation in kidney via regulation of Nox4 (zeige NOX4 Proteine) (NADPH oxidase (zeige NOX1 Proteine) type 4) expression in nephropathy due to diabetes type 1.
pGlcT, together with MEX1, contributes significantly to the export of starch degradation products from chloroplasts in A. thaliana leaves and and that this starch-mediated pathway for photoassimilate export via pGlcT and MEX1 is essential for the growth and development of A. thaliana. [pGlcT]
Low GLUT1 and GLUT3 (zeige SLC2A3 Proteine) expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 (zeige SLC2A4 Proteine) mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin (zeige INS Proteine) responsive.
the different conformations of the GLUT-1 transporter in luminal (blood facing) and abluminal (brain facing) membranes of bovine cerebral endothelial cells arise from differential phosphorylation of GLUT-1
Significant increases in GLUT1 gene expression were observed during early lactation.
Hyperthermia-induced Hsp90 (zeige HSP90 Proteine).eNOS (zeige NOS3 Proteine) preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD (zeige G6PD Proteine) activity.
distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry
Expression of GLUT1 was evaluated in LLC-PK1 cells grown on porous membranes for the development of an artificial kidney.
results suggest that glucose is transported to the axonal cleft intracytoplasmically and delivered to the cleft by GLUT1 transporters
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia.
, glucose transporter type 1, erythrocyte/brain
, hepG2 glucose transporter
, human T-cell leukemia virus (I and II) receptor
, solute carrier family 2, facilitated glucose transporter member 1
, solute carrier family 2, member 1
, Solute carrier family 2 a 1 (facilitated glucose transporter) brain
, Solute carrier family 2, facilitated glucose transporter member 1
, solute carrier family 2 (facilitated glucose transporter), member 1
, solute carrier family 2 member 1
, glucose transporter protein
, glucose transporter type 1
, solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog
, glucose transport protein