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anti-Human VEGFC Antikörper:
anti-Mouse (Murine) VEGFC Antikörper:
anti-Rat (Rattus) VEGFC Antikörper:
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Human Polyclonal VEGFC Primary Antibody für IHC (fro), IHC (p) - ABIN258871
Zampell, Yan, Avraham, Daluvoy, Weitman, Mehrara: HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
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Human Polyclonal VEGFC Primary Antibody für IF (p), IHC (p) - ABIN731723
Zhuo, Jia, Song, Lu, Ding, Wang, Song, Fu, Luo: The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
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Human Monoclonal VEGFC Primary Antibody für ICC, IHC (fro) - ABIN438679
Moussai, Mitsui, Pettersen, Pierson, Shah, Suárez-Fariñas, Cardinale, Bluth, Krueger, Carucci: The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. in The Journal of investigative dermatology 2010
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Human Polyclonal VEGFC Primary Antibody für FACS, IHC (p) - ABIN650694
Yan, Zhu, Yu, Ji, Zhang, Ji, Yan, Chen, Liu, Yin, Lin: Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. in World journal of gastroenterology : WJG 2004
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Rat (Rattus) Polyclonal VEGFC Primary Antibody für IP, ELISA - ABIN1589911
Maertens, Erpicum, Detry, Blacher, Lenoir, Carnet, Péqueux, Cataldo, Lecomte, Paupert, Noel: Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis. in PLoS ONE 2014
Vegfc acts through ERK (zeige MAPK1 Antikörper) to induce sprouting and differentiation of trunk lymphatic progenitors.
data not only reveal a non-canonical function of Mt2 (zeige MT2 Antikörper) in angiogenesis, but also propose Mt2 (zeige MT2 Antikörper) as a novel regulator of vegfc expression.
Vegfc signaling increases mafba (zeige MAFB Antikörper) expression to control downstream transcription
Vegfc is dispensable for facial lymphatic sprouting but not for the complete development of the facial lymphatic network.
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1 (zeige CCBE1 Antikörper), and Vegfc-driven sprouting is enhanced by local Ccbe1 (zeige CCBE1 Antikörper) overexpression. Moreover, Vegfc- and Vegfr3 (zeige FLT4 Antikörper)-dependent Erk (zeige MAPK1 Antikörper) signaling is impaired in the absence of Ccbe1 (zeige CCBE1 Antikörper).
Vegfc has an essential role in lymphangiogenesis [review]
The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 (zeige FLT4 Antikörper) signaling in zebrafish.
Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
Here, we show that vascular endothelial growth factor C (Vegfc), an angiogenic as well as a lymphangiogenic factor, is unexpectedly involved in this process in zebrafish.
VEGF-C and VEGF-C156S genes have roles in the pro-lymphangiogenic growth factor therapy of lymphedema
Transcription of the vascular endothelial growth factor C gene (VEGF-C) and translation of the corresponding protein were significantly up-regulated in swine umbilical vein endothelial cells with classical swine fever virus acute infection.
No difference in bioactivity was detected between porcine relaxin-1 (zeige RLN1 Antikörper) and recombinant human relaxin-2 (zeige RLN1 Antikörper) in either mice or rats.
During progressive ischemia, functional and metabolic benefits of intramyocardial VEGF-C gene transfer were apparent. VEGF-C-induced collateral formation occurred at the site of gene transfer
High expression of VEGF-C in the primary tumour may be a good determinant for detection of occult tumour cells in the lymph nodes of OSCC cases.
document for the first time that CCL5 (zeige CCL5 Antikörper) induces tumor lymphangiogenesis by the induction of VEGF-C in human cancer cells.
Data suggest that the BRG1 (zeige SMARCA4 Antikörper)/STAT3 (zeige STAT3 Antikörper)/VEGFC in tumor-associated lymphangiogenesis might lead to the discovery of novel therapeutic targets in the treatment of cancers with BRG1 (zeige SMARCA4 Antikörper) loss of function.
Studied the effect of recombinant human vascular endothelial growth factor (VEGF)-C on lymphangiogenesis, inflammation, and fibrosis in the mouse kidney using the unilateral ureteral obstruction (UUO); lymphangiogenesis was significantly induced in the UUO+VEGF-C group. In lymphatic endothelial cells, VEGF-C increased the activity and proliferation of such cells and expression of VCAM-1.
In multivariate analysis, only serum VEGF-A (zeige VEGFA Antikörper) correlated to diabetes duration, whereas VEGF-C only correlated to HbA1c and fasting blood glucose.
This study reports that human dendritic cells produce VEGF-C, a cytokine with potent pro-lymphangiogenic activity when stimulated with IFN-gamma (zeige IFNG Antikörper)
Association of coexpressed high levels of VEGF-C and active MMP-9 (zeige MMP9 Antikörper) with lymphatic spreading and local invasiveness of Papillary thyroid carcinoma (PTC (zeige F9 Antikörper)) suggests their potential usefulness as predictive biomarkers of aggressive PTC (zeige F9 Antikörper) behavior.
Data show that VEGF-C, VEGF-D (zeige Figf Antikörper), and VEGFR-3 (zeige FLT4 Antikörper) were expressed in a substantial percentage of breast carcinomas.
By treating LECs with VEGF (zeige VEGFA Antikörper)-C156S and analyzing subsequent changes in gene expression, we identified several 'immediate early (zeige JUN Antikörper)' transcription factors that showed a rapid transient upregulation VEGFR-3 (zeige FLT4 Antikörper) stimulation. these results reveal an important and unanticipated role of HOXD10 (zeige HOXD10 Antikörper) in the regulation of VEGFR-3 (zeige FLT4 Antikörper) signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability.
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time.
lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 (zeige Adamts2 Antikörper) and CCBE1 (zeige CCBE1 Antikörper) spatially and temporally patterns developing lymphatics, and one in which VEGFD (zeige Figf Antikörper) activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth
These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis.
Results suggest that interleukin-6 (IL-6 (zeige IL6 Antikörper)) increases VEGF-C induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Antikörper)-FAK (zeige PTK2 Antikörper)-STAT3 (zeige STAT3 Antikörper) cascade in lymphatic endothelial cells (LECs).
Data show that heparanase-1 (HPA-1 (zeige HPSE Antikörper)) induced shedding of heparan sulfate chain from syndecan-1 (SDC-1 (zeige SDC1 Antikörper)) facilitated the release of vascular endothelial growth factor C (VEGF-C) from SDC-1 (zeige SDC1 Antikörper)/VEGF-C complex into the medium of hepatocarcinoma cell.
Data show that in the MCF-7 breast cancer cell line, only MT1X (zeige MT1X Antikörper) metallothioneins (MTs (zeige NEU2 Antikörper)) positively correlated with vascular endothelial growth factor C (VEGFC).
The findings in this study strongly suggest the following: i) that VEGF-C promotes the proliferative activity and migratory ability of mesenchymal stem cell ; and ii) VEGF-C and Tgfb (zeige TGFB1 Antikörper) reciprocally regulate mesenchymal stem cell commitment to differentiation into lymphatic endothelial or osteoblastic phenotypes, respectively.
The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine.
MT1-MMP (zeige MMP14 Antikörper) directly cleaves LYVE-1 (zeige LYVE1 Antikörper) on lymphatic endothelial cells to inhibit LYVE-1 (zeige LYVE1 Antikörper)-mediated lymphangiogenic responses and restrains the production of VEGF-C.
HA increases lymphangiogenesis in renal fibrosis model and also stimulates vascular endothelial cell growth factor (zeige FGF1 Antikörper)-C production from macrophages through Toll-like receptor 4 (zeige TLR4 Antikörper)-dependent signal pathway
Results showed that the VEGF-C/VEGFR-3 (zeige FLT4 Antikörper) system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
vascular endothelial growth factor C
, vascular endothelial growth factor c
, FLT4 ligand DHM
, vascular endothelial growth factor-related protein
, flt4 ligand
, vascular endothelial growth factor C isoform 129
, vascular endothelial growth factor C isoform 184