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The broad-spectrum activity mediated by UNC2025 in leukemia patient samples and xenograft models, alone or in combination with cytotoxic chemotherapy, supports continued development of MERTK inhibitors for treatment of leukemia
The expression of MerTK and AxlTK varied according to the deposition of immunoglobulin and complements on glomeruli. Both MerTK and AxlTK expressions were increased on glomeruli and varied according to pathological classifications.
Study identified the Gas6 (zeige GAS6 Proteine)/TAM (zeige CCNA1 Proteine) receptor pathway with Tyro3 (zeige TYRO3 Proteine) and Mer as novel targets in colorectal cancer.
MERTK is frequently overexpressed in head and neck squamous cell carcinoma and plays an important role in tumor cell motility.
these data suggest that endogenous GAS6 (zeige GAS6 Proteine) and Mer receptor signaling contribute to the establishment of prostate cancer stem cells in the bone marrow microenvironment
Sequence analysis revealed that the proband was a compound heterozygote with two independent mutations in MERTK, a novel nonsense mutation (c.2179C > T) and a previously reported missense variant (c.2530C > T). The proband's affected brother also had both mutations
this study shows that viral infection sensitizes fetal membranes by MERTK Inhibition
Knockdown of MERTK by shRNA in prostate cancer cells induced a decreased ratio of P-Erk1/2 to P-p38, increased expression of p27, NR2F1, SOX2, and NANOG, induced higher levels of histone H3K9me3 and H3K27me3, and induced a G1/G0 arrest, all of which are associated with dormancy.
MERTK G > A variant affects liver disease, nutrient oxidation and glucose metabolism in NAFLD.
Monocyte-induced MerTK cleavage on proreparative MHCII(LO) cardiac macrophages is a novel contributor to myocardial ischemic reperfusion injury.
Tumor macrophage expression of Mertk is a therapeutic target to prevent tumor recurrence following radiation therapy.
Hypercapnic Acidosis Regulates Mer (zeige ERH Proteine) Tyrosine Kinase Receptor (zeige KDR Proteine) Shedding and Activity.
GC B (zeige NPR2 Proteine) cell-intrinsic sensing of self-RNA, but not self-DNA, from dead cells in GCs (zeige UGCG Proteine) drives enhanced GC responses in Mer (zeige ERH Proteine)(-/-) mice. Mer (zeige ERH Proteine) loss in dendritic cells promotes enhanced T cell activation and proinflammatory cytokine production. Mer (zeige ERH Proteine) immunoregulatory signaling in APCs (zeige APCS Proteine) regulates B cell selection and autoimmunity. The phagocytic and immunomodulatory functions of Mer (zeige ERH Proteine) regulate GC responses preventing autoimmunity.
evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer tyrosine kinase (zeige TYRO3 Proteine) (MerTK) reduces efferocytosis and promotes plaque necrosis and defective resolution.
these results suggest, for the first time, that MerTK is an intracellular negative feedback regulator that inhibits the inflammatory response of lipoteichoic acid -stimulated macrophages
the reciprocal activation of Axl (zeige AXL Proteine) and Mer (zeige ERH Proteine) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Reduced transcription of Mertk, rather than differences in MERTK protein structure, determines the reduced efficiency of apoptotic cell clearance in the Aath4a(DBA/DBA (zeige RPS19 Proteine)) mice, which, in turn, contributes to their increased susceptibility to atherosclerosis.
Axl (zeige AXL Proteine), Mertk and Tyro3 (zeige TYRO3 Proteine) receptors are not required for Zika virus entry and infection.
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
, tyrosine-protein kinase Mer
, c-mer proto-oncogene tyrosine kinase
, MER receptor tyrosine kinase
, tyrosine-protein kinase Mer-like
, STK kinase
, proto-oncogene c-Mer
, receptor tyrosine kinase MerTK
, Tyro 12
, proto-oncogene tyrosine-protein kinase Mer
, Receptor tyrosine tinase gene probably the gene for Rdy
, proto-oncogene tyrosine-protein kinase MER
, retinal dystrophy