anti-HGF (HGF) Antikörper

Human Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh (zeige SHH Antikörper), and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment.

2. TGF-beta (zeige TGFB1 Antikörper) negatively controls the HGF/c-MET pathway by regulating of stemness in glioblastoma.

3. Reduction of fibroblast size upregulates HGF expression, which in turn contributes to loss of collagen, a prominent feature of aged skin.

4. Results of our present study suggest that both IL-6 and HGF derived from Cancer-associated fibroblasts (CAFs)could contribute to the intratumoral androgen metabolism in ER-negative breast carcinoma patients.

5. Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease. Review.

6. this study shows that decidual NK cells facilitate the interaction between trophoblastic and endothelial cells via VEGF-C (zeige VEGFC Antikörper) and HGF

7. We identify HGF, acting through the c-Met receptor, as the key polarity-inducing morphogen (zeige SHH Antikörper), which acts to activate b1-integrin-dependent adhesion. HGF and ECM (zeige MMRN1 Antikörper)-derived integrin signals co-operate via a c-Src (zeige SRC Antikörper)-dependent inhibition of the RhoA (zeige RHOA Antikörper)-ROCK1 (zeige ROCK1 Antikörper) signalling pathway via p190A (zeige GRLF1 Antikörper) RhoGAP (zeige ARHGAP1 Antikörper).

8. High glucose activated Met receptor in HK2 (zeige HK2 Antikörper) cells independently of HGF, via induction of integrin a5b1 and downstream signaling. This mode of Met activation was associated with tubular cell damage and apoptosis and it may represent a novel pathogenic mechanism and a treatment target in diabetic nephropathy.

9. results show that HGF was involved in regulating Chk1 (zeige CHEK1 Antikörper) phosphorylation, and further demonstrate that AKT (zeige AKT1 Antikörper) activity was responsible for this HGF-induced Chk1 (zeige CHEK1 Antikörper) phosphorylation.

10. Lymph node metastasis is strongly associated with expression status of HGF and CD133 at the deep invasive front, suggesting the usefulness of these proteins as independent predictive markers of lymph node metastasis in early gastric cancer.

Mouse (Murine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 (zeige STAT6 Antikörper) phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 (zeige STAT6 Antikörper) nuclear translocation does not occur in response to HGF, precluding the transcriptional activity of STAT6 (zeige STAT6 Antikörper).

2. prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh (zeige SHH Antikörper), and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment.

3. These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.

4. Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor.

5. HGF supports hindlimb motor neurons through c-Met; CNTF (zeige CNTF Antikörper) supports subsets of axial motor neurons through CNTFRalpha (zeige CNTFR Antikörper); and Artemin (zeige ARTN Antikörper) acts as the first survival factor for parasympathetic preganglionic motor neurons through GFRalpha3 (zeige GFRA3 Antikörper)/Syndecan-3 (zeige SDC3 Antikörper) activation.

6. Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex.

7. Our results show that BMF (zeige BMF Antikörper)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.

8. this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis

9. HGF displays an antioxidant response by inducing the glutathione-related protection system.

10. this study revealed that HB-EGF (zeige HBEGF Antikörper) as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.

Cow (Bovine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability.

2. Results confirm the prodevelopmental actions of activin A (zeige INHBA Antikörper) and indicate that CTGF (zeige CTGF Antikörper) may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development.

3. SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.

4. Treatment of the bovine satellite cells (BSC (zeige SLC12A2 Antikörper)) with ephrin-A5 (zeige EFNA5 Antikörper) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (zeige SLC12A2 Antikörper) with hepatocyte growth factor had no immediate effect on cell motility or migration.

5. HGF transiently increases gene transcription of angiotensin-converting enzyme (zeige ACE Antikörper)

Rabbit Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver

Pig (Porcine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. Combined administration of mesenchymal stem cells overexpressing IGF-1 (zeige IGF1 Antikörper) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

2. In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (zeige IGF1 Antikörper)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.

Guinea Pig Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Interaktionspartner

1. the truncated variant of gHGF (a double mutant of N-terminal hairpin and first kringle domains of gHGF, K132E and G134E, gmNK1) protein fused (zeige AXIN1 Antikörper) with His6 tag, the molecular weight of which was about 20.0kDa, which was expressed in Escherichia coli BL21 (DE3) and purified with Ni(2 (zeige VMP1 Antikörper)+)-affinity chromatography.gmNK1 inhibited protein expression levels of fibrosis-related Col (zeige HDAC1 Antikörper) I and alpha-SMA (zeige SMN1 Antikörper) in TGF-beta1 (zeige TGFB1 Antikörper)-activated HSC (zeige FUT1 Antikörper)-T6 cells