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Human GDNF Protein expressed in Escherichia coli (E. coli) - ABIN1686334
Pelletier, Lagacé, St-Amour, Arsenault, Cisbani, Chabrat, Fecteau, Lévesque, Cicchetti: The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2015
results contradict previous studies suggesting that mammalian GFRalpha1 (zeige GFRA1 Proteine) and GDNF cannot bind and activate non-mammalian RET (zeige RET Proteine) and vice versa
the dynamics of glial cell line-derived neurotrophic factor (gdnf) and nitric oxide synthases (nos) mRNA expression in various regions of zebrafish brain
GDNF family ligands including tyrosine kinase receptor (zeige KDR Proteine) RET (zeige RET Proteine) are investigated within the adult zebrafish brain.
GDNF is a major determinant of directed neuritic growth , and GDNF acts by promoting local neurite outgrowth.
These results demonstrated the expression of the GDNF receptorial complex in adult zebrafish cerebellum and suggest an autocrine mode of action of GDNF in Purkinje cells.
These results showed that the expression of GDNF is not probably restricted during development but it might be involved in the physiology of adult zebrafish retina.
The expression of glial cell line-derived neurotrophic factor (GDNF) was not restricted to developmental periods but it seems that this factor might be involved in adult zebrafish brain physiology, as observed in mammals.
Analysis of striatal brain samples confirms increased GDNF expression in lentiviral vector-GDNF treated aged animals that correlates with functional improvements and preserved dopaminergic markers, dependent upon GDNF levels.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Six2 (zeige SIX2 Proteine) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 (zeige SMURF1 Proteine) expression.
Ret (zeige RET Proteine) is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.
identified IFNg (zeige IFNG Proteine), Neurturin (Nrtn (zeige NRTN Proteine)), and glial-derived neurotrophic factor (GDNF) as ligands with unexpected roles in promoting neurogenic differentiation (zeige NEUROD1 Proteine) of Neural Precursor Cells in vivo.
Using an organ culture system for prostate development and Ret mutant mice, we demonstrate that RET-mediated GDNF signaling in UGS increases proliferation of mesenchyme cells and suppresses androgen-induced proliferation and differentiation of prostate epithelial cells, inhibiting prostate development.
The GDNF-GFRalpha1 (zeige GFRA1 Proteine) complex is essential for proper hippocampal circuit development.
In SOD1(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha, TNFR1 and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 completely abolished GDNF rises in both SOD1(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration and disease progression
GDNF signals were able to induce the stratified aggregate formation of GFRalpha1 (zeige GFRA1 Proteine)-positive undifferentiated spermatogonia
Our results show the existence of two subpopulations of peptidergic nociceptors characterized by the presence of CGRP (zeige CALCA Proteine), one expressing BDNF (zeige BDNF Proteine) (plus SP), the other expressing GDNF (plus SST (zeige SST Proteine)), suggesting a different role for these two neurotrophic factors in the discrimination of specific painful stimuli modalities.
The data of this study suggested that short-term exposure to hyperoxic conditions can affect the regulation and expression of BDNF (zeige BDNF Proteine) potentially leading to alterations in neural development.
Spatial expression analysis by whole-mount in situ hybridization showed that the GDNF mRNA was predominantly detected in somites, pronephros, pharyngeal arches, epibranchial placodes, digestive tract and some of the lateral line structure.
These findings provide preliminary evidence that silencer II hypermethylation in the gdnf promoter II may underlie high gene transcription in high-grade glioma cells.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
No correlations between the levels of serum neurotrophins and the severity of ADHD were observed. These results suggest that elevated serum GDNF and NTF3 (zeige NTF3 Proteine) levels may be related to ADHD in children.
BDNF (zeige BDNF Proteine) and GDNF interact with the 5-HT (zeige DDC Proteine)-system of the brain through feedback mechanisms engaged in autoregulation
the synergistic effect of Gas1 (zeige GAS1 Proteine) inhibition and GDNF against glutamate (zeige GRIN1 Proteine)-induced cell injury in human SH-SY5Y neuroblastoma (zeige ARHGEF16 Proteine) cells, is reported.
Study shows no correlation between GDNF rs884344 and rs3812047 polymorphisms and subjects with tinnitus.
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease.
, Glial cell line derived neutrophic factor
, astrocyte-derived trophic factor
, glial cell line derived neurotrophic factor
, glial cell line-derived neurotrophic factor
, glial cell line-derived neurotrophic factor long form
, glial cell derived neurotrophic factor
, glial cell-line derived neurotrophic factor
, neurotrophic factor
, glial cell line-derived neurotrophic factor a
, glia-derived neurotrophic growth factor