anti-ERBB3 (ERBB3) Antikörper

Bezeichnung:: anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Antikörper (ERBB3)

Auf www.antikoerper-online.de finden Sie aktuell 530 V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ERBB3 Proteine (45) und ERBB3 Kits (36) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 642 ERBB3 Produkte verfügbar.

Synonyme:: c-erbB-3, c-erbB3, C76256, Erbb-3, ERBB3, erbB3-S, Erbb3r, HER-3, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	ERBB3	2065	P21860
	ERBB3	13867	Q61526
	ERBB3	29496	Q62799
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human ERBB3 Antikörper:

anti-Mouse (Murine) ERBB3 Antikörper:

anti-Rat (Rattus) ERBB3 Antikörper:

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Verknüpfte Pathways mit anti-ERBB3 Antikörper

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Am meisten referenzierte anti-ERBB3 Antikörper

Human Polyclonal ERBB3 Primary Antibody für CyTOF, FACS - ABIN4899525 : Lin, Cheng, Lee, Ye, Tsai, Kim, Pasqualini, Arap, Navone, Tu, Hu, Yu-Lee, Logothetis: A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation. in Oncogene 2008 (PubMed)
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Human Polyclonal ERBB3 Primary Antibody für DB, WB - ABIN1881314 : Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. in BMC medical genetics 2009 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für FACS - ABIN4896267 : MacLeod, Elgadi, Bossi, Sankar, Pisio, Agopsowicz, Sharon, Graham, Hitt: HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice. in Cancer gene therapy 2012 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für FACS - ABIN4896268 : Richards, Zweidler-McKay, Van Roy, Speleman, Trevino, Zage, Hughes: Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo. in Cancer 2010 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899526 : Liu, Leng, Gunasekaran, Pentony, Shen, Howard, Stoops, Manchulenko, Razinkov, Liu, Fanslow, Hu, Sun, Hasegawa, Clark, Foltz, Yan: A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism. in The Journal of biological chemistry 2015 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899527 : Lin, Lee, Choueiri, Wen, Mathew, Ye, Do, Navone, Kim, Tu, Yu-Lee, Logothetis: Soluble ErbB3 levels in bone marrow and plasma of men with prostate cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für IHC (f), IHC (fro) - ABIN967437 : Carraway, Cantley: A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. in Cell 1994 (PubMed)
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Human Polyclonal ERBB3 Primary Antibody für FACS, IHC (p) - ABIN391949 : Katoh, Yazaki, Sugimura, Terada: c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. in Biochemical and biophysical research communications 1993 (PubMed)
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Polyclonal ERBB3 Primary Antibody für IF, IHC (p) - ABIN4948293 : Yarden, Sliwkowski: Untangling the ErbB signalling network. in Nature reviews. Molecular cell biology 2001 (PubMed)
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Polyclonal ERBB3 Primary Antibody für IF, IHC (p) - ABIN4948299 : Kobayashi, Iwamatsu, Shinohara-Kanda, Ihara, Fukui: Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. in Oncogene 2003 (PubMed)
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Weitere Antikörper gegen ERBB3 Interaktionspartner

Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

Study shows ErbB3 expression was markedly decreased in suicide completers compared to controls.
EGFR (zeige EGFR Antikörper) expression is increased in oesophageal and gastric adenocarcinomas after neoadjuvant therapy and was significantly associated with a prolonged overall survival in univariable analysis.
Using time-resolved-fluorescence energy transfer (TR-FRET), we demonstrated that in the presence of recombinant NRG1 (zeige NRG1 Antikörper), binding of 9F7-F11 (zeige F11 Antikörper) to HER3 is increased, whereas that of ligand-competing anti-HER3 antibodies (H4B-121, U3-1287, Ab#6 (zeige NBPF10 Antikörper), Mab205.10.2, and MOR09825) is decreased.
This study uncovers a direct relationship between HPV infection and HER3 in head and neck squamous cell carcinomas and provides a rationale for the clinical evaluation of targeted HER3 therapy for the treatment of HPV(+) patients.
Cetuximab treatment induced HER3 activation and HER2 (zeige ERBB2 Antikörper)/HER3 dimerization in head and neck squamous cell carcinoma cell lines. Cetuximab induces HER3 expression and activation in HNSCC cell lines. Upregulation of HER3 by cetuximab is one mechanism underlying resistance to EGFR (zeige EGFR Antikörper) inhibition in HNSCC.
High HER3 expression is associated with breast cancer.
hematopoietic expression of ERBB3 appears to be highest in bone marrow common myeloid and megakaryocyte-erythrocyte progenitors. Identified ERBB3 as a candidate gene for predisposition to erythroid MDS (zeige PAFAH1B1 Antikörper)/AML (zeige RUNX1 Antikörper)
Given an aberrant high level of sPLA2IIa in the tumor microenvironment that should be much higher than that in the blood, our findings support the notion that sPLA2IIa functions as a ligand for EGFR (zeige EGFR Antikörper) family receptors and supports CSC properties via HER/ERBB (zeige EGFR Antikörper)-elicited signaling, which may contribute to resistance to therapy and cancer progression
High LINC00052 levels predict activation of HER3-mediated signaling, promoting breast cancer growth.
EHF (zeige EHF Antikörper) is a novel functional oncogene (zeige RAB1A Antikörper) in thyroid cancer by transcriptionally regulating HER2 (zeige ERBB2 Antikörper) and HER3, and may represent a potential therapeutic target for this cancer

Rhesus Monkey V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.

Pig (Porcine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair

Mouse (Murine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

These studies demonstrate that ErbB3, like ErbB4 (zeige ERBB4 Antikörper), enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt (zeige AKT1 Antikörper) and STAT5A (zeige STAT5A Antikörper), two targets crucial for lactation.
The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 (zeige ATOH1 Antikörper) levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
Our results support a role for the hepatocellular ERBB (zeige EGFR Antikörper) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (zeige EGFR Antikörper)-ERBB3 DKO models, suggesting that EGFR (zeige EGFR Antikörper)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (zeige EGFR Antikörper) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (zeige SHH Antikörper)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Antikörper)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Antikörper) protein, epidermal growth factor (EGF (zeige EGF Antikörper)) and receptors of the ErbB (zeige EGFR Antikörper) receptors ErbB1 (zeige EGFR Antikörper), ErbB2 (zeige ERBB2 Antikörper) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (zeige ERBB4 Antikörper) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (zeige AKT1 Antikörper) pathway and promoting erbB2 (zeige ERBB2 Antikörper)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (zeige STAT3 Antikörper) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.

Zebrafish V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
Transcription of her3 is repressed rather than activated by Notch (zeige NOTCH1 Antikörper) signalling.

ERBB3 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Alternative names and synonyms associated with ERBB3

erb-b2 receptor tyrosine kinase 3 (ERBB3) Antikörper
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) Antikörper
erb-b2 receptor tyrosine kinase 3 (Erbb3) Antikörper
hairy-related 3 (her3) Antikörper

c-erbB-3 Antikörper
c-erbB3 Antikörper
C76256 Antikörper
Erbb-3 Antikörper
ERBB3 Antikörper
erbB3-S Antikörper
Erbb3r Antikörper
HER-3 Antikörper
Her3 Antikörper
LCCS2 Antikörper
MDA-BF-1 Antikörper
nuc-ErbB3 Antikörper
p45-sErbB3 Antikörper
p85-sErbB3 Antikörper
p180-ErbB3 Antikörper

Bezeichner auf Proteinebene für ERBB3

proto-oncogene-like protein c-ErbB-3 , receptor tyrosine-protein kinase erbB-3 , tyrosine kinase-type cell surface receptor HER3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) , receptor tyrosine kinase ErbB3 , receptor tyrosine-protein kinase erbB-3-like , avian erythroblastosis oncogene B 3 receptor , c-erbB-3 , glial growth factor receptor , receptor tyrosine kinase , avian erythroblastosis oncogene B 3 , c-erbB3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 , transcription factor HES-3 , v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

GENE ID	SPEZIES
2065	Homo sapiens
711407	Macaca mulatta
100008807	Oryctolagus cuniculus
100126862	Sus scrofa
481105	Canis lupus familiaris
100468735	Ailuropoda melanoleuca
13867	Mus musculus
29496	Rattus norvegicus
100712946	Cavia porcellus
30289	Danio rerio
100059216	Equus caballus
785655	Bos taurus

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