anti-ERBB3 (ERBB3) Antikörper

Bezeichnung:: anti-V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Antikörper (ERBB3)

Auf www.antikoerper-online.de finden Sie aktuell 534 V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ERBB3 Proteine (49) und ERBB3 Kits (41) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 654 ERBB3 Produkte verfügbar.

Synonyme:: c-erbB-3, c-erbB3, C76256, Erbb-3, ERBB3, erbB3-S, Erbb3r, Her3, LCCS2, MDA-BF-1, nuc-ErbB3, p45-sErbB3, p85-sErbB3, p180-ErbB3

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	ERBB3	2065	P21860
	ERBB3	13867	Q61526
	ERBB3	29496	Q62799
Alle Spezies anzeigen Weitere Synonyme anzeigen

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anti-Human ERBB3 Antikörper:

anti-Mouse (Murine) ERBB3 Antikörper:

anti-Rat (Rattus) ERBB3 Antikörper:

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Verknüpfte Pathways mit anti-ERBB3 Antikörper

Weitere Produktkategorien zu ERBB3 Antikörper

Am meisten referenzierte anti-ERBB3 Antikörper

Human Polyclonal ERBB3 Primary Antibody für CyTOF, FACS - ABIN4899525 : Lin, Cheng, Lee, Ye, Tsai, Kim, Pasqualini, Arap, Navone, Tu, Hu, Yu-Lee, Logothetis: A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation. in Oncogene 2008 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für FACS - ABIN4896268 : MacLeod, Elgadi, Bossi, Sankar, Pisio, Agopsowicz, Sharon, Graham, Hitt: HER3 targeting of adenovirus by fiber modification increases infection of breast cancer cells in vitro, but not following intratumoral injection in mice. in Cancer gene therapy 2012 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899526 : Liu, Leng, Gunasekaran, Pentony, Shen, Howard, Stoops, Manchulenko, Razinkov, Liu, Fanslow, Hu, Sun, Hasegawa, Clark, Foltz, Yan: A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism. in The Journal of biological chemistry 2015 (PubMed)
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Human Polyclonal ERBB3 Primary Antibody für DB, WB - ABIN1881314 : Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. in BMC medical genetics 2009 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für IHC (f), IHC (fro) - ABIN967437 : Carraway, Cantley: A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. in Cell 1994 (PubMed)
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Human Polyclonal ERBB3 Primary Antibody für FACS, IHC (p) - ABIN391949 : Katoh, Yazaki, Sugimura, Terada: c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. in Biochemical and biophysical research communications 1993 (PubMed)
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Polyclonal ERBB3 Primary Antibody für IF, IHC (p) - ABIN4948293 : Yarden, Sliwkowski: Untangling the ErbB signalling network. in Nature reviews. Molecular cell biology 2001 (PubMed)
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Polyclonal ERBB3 Primary Antibody für IF, IHC (p) - ABIN4948299 : Kobayashi, Iwamatsu, Shinohara-Kanda, Ihara, Fukui: Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. in Oncogene 2003 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für ELISA, WB - ABIN969113 : Sakai, Yokote, Murakami-Murofushi, Tamura, Saijo, Nishio: Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. in Cancer science 2007 (PubMed)
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Human Monoclonal ERBB3 Primary Antibody für ICC, ELISA - ABIN969114 : Sassen, Rochon, Wild, Hartmann, Hofstaedter, Schwarz, Brockhoff: Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients. in Breast cancer research : BCR 2008 (PubMed)
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Weitere Antikörper gegen ERBB3 Interaktionspartner

Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

ERBB3 mutations can be found in a wide variety of tumour types, and can be used to select treatment with HER family inhibitors.
identified P2RX2 (zeige P2RX2 Antikörper), KCNQ5 (zeige KCNQ5 Antikörper), ERBB3 and SOCS3 (zeige SOCS3 Antikörper) to be associated with the progression of age-related hearing impairment
In this study, authors analyzed the immunoexpression of EGFR (zeige EGFR Antikörper), HER2 (zeige ERBB2 Antikörper) (EGFR2) and HER3 (EGFR3) in 41 cases of serous borderline ovarian tumors and carcinomas, in relation to the degree of differentiation and tumor stage.
Results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 (zeige ERBB4 Antikörper) subsequent to increased levels of acetyl-histone and activation of ERK (zeige EPHB2 Antikörper) signaling.
miR152 was found to be involved in the proliferation and metastasis of ovarian cancer cells through repression of ERBB3 expression.
NRG1 (zeige NRG1 Antikörper)-dependent activation of HER3 induces primary resistance to trastuzumab in HER2 (zeige ERBB2 Antikörper)-overexpressing breast cancer cells. HER3 monoclonal antibody combined with trastuzumab may serve as a treatment choice for patients with primary resistance to trastuzumab.
This phase Ib study was designed to determine the MTD (zeige MT1E Antikörper), safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) mAb SAR256212 in combination with the oral PI3K (zeige PIK3CA Antikörper) inhibitor SAR245408 for patients with metastatic or locally advanced solid tumors.
the present study suggests that HER2 (zeige ERBB2 Antikörper) has an important role in the regulation of the cancer stem-like cells phenotype in ALK translocated lung cancers that is mainly orchestrated by HER2 (zeige ERBB2 Antikörper)/HER3 heterodimers.
HER3 phosphorylation by EGFR (zeige EGFR Antikörper) depends on the ability of EGFR (zeige EGFR Antikörper) to homo-oligomerize.
To determine additional resistance mechanisms to cetuximab treatment besides HER3 signaling.

Rhesus Monkey V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.

Pig (Porcine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair

Mouse (Murine) V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) Interaktionspartner

Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1 (zeige NRG1 Antikörper)), which acts on luminal cells via Erbb3 and Erbb4 (zeige ERBB4 Antikörper) receptors.
The authors demonstrate that ErbB3 signaling is required for the embryonic development of the enteric nervous system.
These studies demonstrate that ErbB3, like ErbB4 (zeige ERBB4 Antikörper), enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt (zeige AKT1 Antikörper) and STAT5A (zeige STAT5A Antikörper), two targets crucial for lactation.
The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 (zeige ATOH1 Antikörper) levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
Our results support a role for the hepatocellular ERBB (zeige EGFR Antikörper) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (zeige EGFR Antikörper)-ERBB3 DKO models, suggesting that EGFR (zeige EGFR Antikörper)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (zeige EGFR Antikörper) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (zeige SHH Antikörper)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Antikörper)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Antikörper) protein, epidermal growth factor (EGF (zeige EGF Antikörper)) and receptors of the ErbB (zeige EGFR Antikörper) receptors ErbB1 (zeige EGFR Antikörper), ErbB2 (zeige ERBB2 Antikörper) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (zeige ERBB4 Antikörper) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (zeige AKT1 Antikörper) pathway and promoting erbB2 (zeige ERBB2 Antikörper)-driven mammary/breast tumorigenesis.

ERBB3 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Alternative names and synonyms associated with ERBB3

erb-b2 receptor tyrosine kinase 3 (ERBB3) Antikörper
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) Antikörper
erb-b2 receptor tyrosine kinase 3 (Erbb3) Antikörper

c-erbB-3 Antikörper
c-erbB3 Antikörper
C76256 Antikörper
Erbb-3 Antikörper
ERBB3 Antikörper
erbB3-S Antikörper
Erbb3r Antikörper
Her3 Antikörper
LCCS2 Antikörper
MDA-BF-1 Antikörper
nuc-ErbB3 Antikörper
p45-sErbB3 Antikörper
p85-sErbB3 Antikörper
p180-ErbB3 Antikörper

Bezeichner auf Proteinebene für ERBB3

proto-oncogene-like protein c-ErbB-3 , receptor tyrosine-protein kinase erbB-3 , tyrosine kinase-type cell surface receptor HER3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) , receptor tyrosine kinase ErbB3 , receptor tyrosine-protein kinase erbB-3-like , avian erythroblastosis oncogene B 3 receptor , c-erbB-3 , glial growth factor receptor , receptor tyrosine kinase , avian erythroblastosis oncogene B 3 , c-erbB3 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 , v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

GENE ID	SPEZIES
2065	Homo sapiens
711407	Macaca mulatta
100008807	Oryctolagus cuniculus
100126862	Sus scrofa
481105	Canis lupus familiaris
100468735	Ailuropoda melanoleuca
13867	Mus musculus
29496	Rattus norvegicus
100712946	Cavia porcellus
100059216	Equus caballus
785655	Bos taurus

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