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anti-Human Amphiregulin Antikörper:
anti-Mouse (Murine) Amphiregulin Antikörper:
anti-Rat (Rattus) Amphiregulin Antikörper:
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Human Polyclonal Amphiregulin Primary Antibody für IF (p), IHC (p) - ABIN704996
Jiang, Song, Li, Guo, Wu, Li, Guo, Shi, Bi, Jonas: Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia. in EBioMedicine 2017
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Human Polyclonal Amphiregulin Primary Antibody für WB - ABIN610556
Chen, Parsons, Brautigan: Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. in The Journal of biological chemistry 1994
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Human Amphiregulin Primary Antibody für ELISA - ABIN638842
Oliveras-Ferraros, Cufí, Queralt, Vazquez-Martin, Martin-Castillo, de Llorens, Bosch-Barrera, Brunet, Menendez: Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. in British journal of cancer 2012
Human Polyclonal Amphiregulin Primary Antibody für IHC, IHC (p) - ABIN4280428
Barton, DAmato, Gordon, Lind, Spoelstra, Babbs, Heinz, Elias, Jedlicka, Jacobsen, Richer: Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo. in Molecular cancer therapeutics 2015
Results show that AREG expression is up-regulated in gastric tumor and its co-expression with TROP2 (zeige TACSTD2 Antikörper) protein is associated with TNM (zeige ODZ1 Antikörper) stage, tumor size, lymph node metastases, and distant metastases.
secretion of IL-13 (zeige IL13 Antikörper) and amphiregulin suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
EGF (zeige EGF Antikörper)-AREG interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium.
AREG expression may be useful for identifying CRTC1 (zeige CRTC1 Antikörper)-MAML2 (zeige MAML2 Antikörper)-positive mucoepidermoid carcinomas and as a marker for favorable prognosis.
Amphiregulin enhances VEGF-A (zeige VEGFA Antikörper) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (zeige MLXIP Antikörper)-206 via FAK (zeige PTK2 Antikörper)/c-Src (zeige SRC Antikörper)/PKCdelta (zeige PKCd Antikörper) pathway.
Amphiregulin plays an important role in lung neoplasm resistance to amrubicinol
EREG (zeige EREG Antikörper) and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site.
These findings demonstrate the posttranslational regulation of Foxp3 (zeige FOXP3 Antikörper) expression by AREG in cancer patients through AREG/EGFR (zeige EGFR Antikörper)/GSK-3beta (zeige GSK3b Antikörper) signaling, which could lead to Foxp3 (zeige FOXP3 Antikörper) protein degradation in Treg cells and a potential therapeutic target for cancer treatment.
blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 (zeige TP53 Antikörper) adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis
Low AREG expression is associated with gastric cancer.
activated alveolar macrophages also exerted a protective effect on the lung tissues by producing high-level amphiregulin in lipopolysaccharide-induced acute lung injury
AREG overexpression in osteoblasts induces a transient high bone mass phenotype in the trabecular compartment of the appendicular skeleton by a growth-related, non-cell autonomous mechanism
AREG-silenced keratinocytes plays an important role in regulation cell proliferation.
Hepatic CD206 (zeige MRC1 Antikörper)-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection.
Areg may have a role in classically activated macrophages
After activation with IL-33 (zeige IL33 Antikörper), expression of AREG is a dominant functional signature of gut (zeige GUSB Antikörper)-associated IL-33 (zeige IL33 Antikörper)-dependent group 2 innate lymphoid cells. The frequency and number of AREG-expressing ILC2s increases following intestinal injury.
AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH (zeige SAMSN1 Antikörper), suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD (zeige TSC2 Antikörper).
hormones and/or factors in addition to E that upregulate AREG can promote mammary gland development and have the potential to affect breast cancer risk associated with pubertal mammary gland development
Our data show that AREG is essential for ultraviolet therapy-induced contact hypersensitivity suppression.
Pre-maturation with cAMP modulators in conjunction with EGF (zeige EGF Antikörper)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
LH and AREG decrease BNP (zeige BNC2 Antikörper) and CNP (zeige NPPC Antikörper) production in granulosa cells and down-regulate NPR2 (zeige NPRL2 Antikörper) expression in cumulus cells, which together decreased oocyte cGMP to levels that permit meiotic resumption.
cloning the complete coding region; comparison of endometrial amphiregulin mRNA expression in Meishan and White composite pigs
Amphiregulin co-operates with bone morphogenetic protein 15 (zeige BMP15 Antikörper) to increase bovine oocyte developmental competence.
Data suggest that epidermal growth factor receptor (zeige EGFR Antikörper) B [ErbB (zeige EGFR Antikörper)] isoforms and their ligands (epidermal growth factor (zeige EGF Antikörper) [EGF (zeige EGF Antikörper)], amphiregulin [AREG], and neuregulin-1 (zeige NRG1 Antikörper) [NRG1 (zeige NRG1 Antikörper)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
colorectum cell-derived growth factor
, schwannoma-derived growth factor
, amphiregulin (schwannoma-derived growth factor)
, amphiregulin long form
, amphiregulin B
, Schwannoma-derived growth factor