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once inside the nucleus, P2X6 subunit interacts with the splicing factor 3A1, which ultimately results in a reduction of the mRNA splicing activity
in macrophages, SF3a has significant preference for mRNA splicing events within innate immune signaling pathways compared with other biological pathways, thereby affecting the splicing of specific genes in the TLR signaling pathway
Polymorphisms in SF3A1 gene is associated with pancreatic cancer.
SF3A1 polymorphisms are not associated with Colorectal Cancer Risk.
the SF3A mRNA splicing complex controls production of a negative regulator of TLR signaling that limits the extent of innate immune activation.
show that U1-SL4 interacts with the SF3A1 protein of the U2 snRNP
SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
, splicing factor 3a, subunit 1
, splicing factor 3A subunit 1
, ubiquitin domain-containing protein
, Splicing factor 3 subunit 1
, splicing factor 3 subunit 1
, splicing factor 3a, subunit 1, 120kDa
, SAP 114
, pre-mRNA processing 21
, pre-mRNA splicing factor SF3a (120 kDa subunit)
, spliceosome-associated protein 114