Splicing Factor 3a, Subunit 1 Proteine (SF3A1)

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

• CG16941 gene product from transcript CG16941-RA (CG16941)
• SWAP/Surp domain-containing protein (sf3a1)
• splicing factor 3a, subunit 1 (sf3a1)
• splicing factor 3a, subunit 1 (spl1)
• splicing factor 3a, subunit 1 (Sf3a1)
• Alle Gen-Bezeichnungen
• splicing factor 3a subunit 1 (SF3A1)

• 1200014H24Rik Protein
• 5930416L09Rik Protein
• AI159724 Protein
• DDBDRAFT_0168938 Protein
• DDBDRAFT_0233180 Protein
• Alle Synonyme
• DDB_0168938 Protein
• DDB_0233180 Protein
• Dmel\\CG16941 Protein
• PRP21 Protein
• PRPF21 Protein
• SAP114 Protein
• SF3a1 Protein
• SF3A120 Protein
• si:dz150f13.2 Protein
• wu:fc38e01 Protein
• wu:fc50a11 Protein
• wu:fj37c05 Protein
• zgc:65786 Protein

CG16941-PA , splicing factor 3a, subunit 1 , splicing factor 3A subunit 1 , ubiquitin domain-containing protein , Splicing factor 3 subunit 1 , SF3a120 , splicing factor 3 subunit 1 , splicing factor 3a, subunit 1, 120kDa , SAP 114 , pre-mRNA processing 21 , pre-mRNA splicing factor SF3a (120 kDa subunit) , spliceosome-associated protein 114