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This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism.
Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase.
These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway.
Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v.
data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008
, cardiac-MyBP-C associated Ca/CaM kinase
, cardiac-MyBP-C-associated Ca/CaM kinase
, putative myosin light chain kinase 3
, cardiac MLCK
, cardiac-specific myosin light chain kinase
, myosin light chain kinase 3
, Putative myosin light chain kinase 3