anti-Myogenic Factor 6 (MYF6) Antikörper

Zebrafish Myogenic Factor 6 (MYF6) Interaktionspartner

1. Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle

2. Data suggest that the transcript Mrf4_tv2 is involved in alignment of muscle fibers, and Mrf4_tv1 might have cooperative function with Mrf4_tv2 in muscle fiber alignment, without affecting the muscle-nerve connection.

3. mrf4 but not myog can fully rescue myogenesis in the myod/myf5 double morphant via a selective and robust activation of myod. Rescue does not happen spontaneously, because the gene is expressed only at the onset of muscle differentiation

Mouse (Murine) Myogenic Factor 6 (MYF6) Interaktionspartner

1. findings identified miR-374b directly targets Myf6 and negatively regulates myogenesis

2. Mrf4 has a role in priming embryonic founder cells to become adult muscle stem cells

3. Intrinsic muscle factor MRF4 plays an important role in maintenance of neuromuscular junctions.

4. Data demonstrated that Myf6 is Tceal7 upstream transactivators using transcriptional assays.

5. MRF4 targets the proximal region of M-cadherin promoter and bind the E4-box.

6. Hox genes produce global patterns in the axial skeleton; Myf5 and Myf6 have roles in rib formation

7. Mrf4 expression precedes or is contemporaneous with that of Myf5, suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis

8. an enhancer element directs MRF4 gene expression primarily in fast muscle fibers

9. elements within a 7.5-kb promoter fragment of the MRF4 gene are sufficient to drive the embryonic wave of expression very similar to the endogenous gene in somites of mouse embryos

10. skeletal muscle is present in the new Myf5:Myod double-null mice only when Mrf4 expression is not compromised

11. Expression of the Na(V) 1.4 Na+ channel was substantially reduced in MRF4-null mice, both in the surface membrane and at neuromuscular junctions. Thus, MRF4 appears to play a novel and selective role in adult muscle.

12. Taken together, these results indicate that MRF4 and MyoD play competitive roles in myogenesis by stimulating cell proliferation and differentiation, respectively.

Xenopus laevis Myogenic Factor 6 (MYF6) Interaktionspartner

1. A conserved myf6 promoter drives transgenic expression in Xenopus embryonic somites and adult muscle.

2. XMRF4 protein does not require innervation during muscle regeneration

3. XMRF4 protein accumulated in somite nuclei slightly after XMRF4 transcripts

Human Myogenic Factor 6 (MYF6) Interaktionspartner

1. The myogenic basic helix-loop-helix family of transcription factors, MyoD, Myf5, myogenin, and MRF4, can each activate the muscle differentiation program.

2. Myogenin and myogenic differentiation factor D (MyoD) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (myf)-5 mRNA increased in young only (P < 0.05). Myf-6 protein increased (P < 0.05) in both young and old.

Pig (Porcine) Myogenic Factor 6 (MYF6) Interaktionspartner

1. Pietrain pigs exhibited significant higher expression of MYF6 and hypermethylated E2F1 binding element within MYF6 5'-regulatory region as compared with Duroc pigs.

2. The expression level of Myf6 gene does not indicate significant differences between muscles, ages and breeds.

3. The porcine MYF6 gene was amplified and sequenced and compared with MYF6 gene sequences of other species. The amino acid sequence was deduced and an interspecies homology analysis was performed.

4. Associations between the genotype at the MYF6 locus and carcass quality traits appeared to be breed-dependent.

Cow (Bovine) Myogenic Factor 6 (MYF6) Interaktionspartner

1. MRF4 and H-FABP genes are associated with growth traits in Qinchuan cattle and related hybrids [MRF4]