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anti-Human MED26 Antikörper:
anti-Mouse (Murine) MED26 Antikörper:
anti-Rat (Rattus) MED26 Antikörper:
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EAF1 (zeige SRCAP Antikörper) (239-268) and TAF7 (zeige TAF7 Antikörper) (205-235) peptide interactions were both mapped to the same groove formed by H3 and H4 helices of MED26 N-terminal domain.
the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7 (zeige TAF7 Antikörper)) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
MED26 can function as a molecular switch that interacts first with TFIID (zeige TBP Antikörper) in the Pol II (zeige 0 Antikörper) initiation complex and then exchanges TFIID (zeige TBP Antikörper) for complexes containing ELL (zeige ELL Antikörper)/EAF and P-TEFb (zeige CCNT1 Antikörper) to facilitate transition of Pol II (zeige 0 Antikörper) into the elongation stage of transcription.
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
findings identify MED19 (zeige MED19 Antikörper)/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
mediator of RNA polymerase II transcription subunit 26 , CRSP complex subunit 7 , CRSP70 , mediator complex subunit 26 , ARC70 , activator-recruited cofactor 70 kDa component , cofactor required for Sp1 transcriptional activation subunit 7 , cofactor required for Sp1 transcriptional activation, subunit 7 (70kD) , cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa , transcriptional coactivator CRSP70 , solute carrier family 35, member E1 , CRSP70-like protein